Title:
SIRNA FOR INHIBITING HTT GENE EXPRESSION, AND PRECURSOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/115141
Kind Code:
A1
Abstract:
Provided are an siRNA for inhibiting HTT gene expression and a precursor sequence thereof, an expression vector comprising the siRNA or the precursor sequence thereof, an application thereof in preparation of a drug for treating Huntington's disease, and a pharmaceutical preparation and pharmaceutical composition containing the siRNA, the precursor sequence or the expression vector. The siRNA is selected from the following: SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO.:5, or a combination thereof.
Inventors:
CHEN XI (CN)
ZHANG LI (CN)
PEI ZHONG (CN)
WU TENGTENG (CN)
LIU JIN (CN)
YU MENGCHAO (CN)
XIA YUGUI (CN)
TU SHENG (CN)
LIN QIAOFANG (CN)
ZHANG LI (CN)
PEI ZHONG (CN)
WU TENGTENG (CN)
LIU JIN (CN)
YU MENGCHAO (CN)
XIA YUGUI (CN)
TU SHENG (CN)
LIN QIAOFANG (CN)
Application Number:
PCT/CN2020/132256
Publication Date:
June 17, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
NANJING YOUZHIYUAN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C12N15/113; A61K31/7105; A61K31/713; A61P25/14; C12N15/63
Domestic Patent References:
| WO2018204803A1 | 2018-11-08 | |||
| WO2019060726A1 | 2019-03-28 |
Foreign References:
| US10093927B2 | 2018-10-09 | |||
| CN101052717A | 2007-10-10 | |||
| CN109831916A | 2019-05-31 | |||
| CN109971756A | 2019-07-05 |
Other References:
SAMBROOK ET AL.: "Molecular Cloning: Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 4074826A4
See also references of EP 4074826A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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