Title:
SIRNA MOLECULE FOR REGULATING PCSK9 GENE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/241591
Kind Code:
A1
Abstract:
Provided are a small interfering RNA (siRNA) used to inhibit the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) in a cell, a vector comprising nucleotides encoding same, and a cell, as well as a method using the siRNA, the vector or the cell for the treatment of diseases or symptoms associated with the expression of PCSK9 in a subject.
Inventors:
HUANG JINYU (CN)
GUO HONGLI (CN)
CAI GUOQING (CN)
YANG XIAOYAN (CN)
GUO HONGLI (CN)
CAI GUOQING (CN)
YANG XIAOYAN (CN)
Application Number:
PCT/CN2023/100015
Publication Date:
December 21, 2023
Filing Date:
June 13, 2023
Export Citation:
Assignee:
SHANGHAI RONA THERAPEUTICS CO LTD (CN)
International Classes:
C12N15/113; A61K31/7105; A61K31/713; A61K48/00; A61P1/16; A61P3/06; A61P9/00
Domestic Patent References:
| WO2020233655A1 | 2020-11-26 |
Foreign References:
| CN108220295A | 2018-06-29 | |||
| CN112368381A | 2021-02-12 | |||
| CN110959011A | 2020-04-03 | |||
| US20160303054A1 | 2016-10-20 | |||
| CN109957565A | 2019-07-02 |
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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