Title:
SIRNA AND THEIR USE IN METHODS AND COMPOSITIONS FOR INHIBITING THE EXPRESSION OF THE FLAP GENE
Document Type and Number:
WIPO Patent Application WO2015059116
Kind Code:
A3
Abstract:
The invention relates to si RNA molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the FLAP gene. The invention also relates to the use of said si RNAs molecules in the treatment and/or prevention of an eye condition characterised by increased expression and/or activity of FLAP gene, preferably said eye condition is conjunctivitis and/or an ocular allergy such as seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and giant papillary conjunctivitis.
Inventors:
JIMENEZ ANA ISABEL (ES)
PAÑEDA COVADONGA (ES)
MARTINEZ TAMARA (ES)
PAÑEDA COVADONGA (ES)
MARTINEZ TAMARA (ES)
Application Number:
PCT/EP2014/072500
Publication Date:
August 20, 2015
Filing Date:
October 21, 2014
Export Citation:
Assignee:
SYLENTIS SAU (ES)
International Classes:
C12N15/113; A61K31/713; A61P27/02; A61P37/08
Domestic Patent References:
| WO2011137363A1 | 2011-11-03 | |||
| WO2008104978A2 | 2008-09-04 | |||
| WO2009105723A2 | 2009-08-27 | |||
| WO2008030369A1 | 2008-03-13 | |||
| WO2011148193A1 | 2011-12-01 | |||
| WO2004015107A2 | 2004-02-19 |
Other References:
A. MUSIYENKO ET AL: "A Novel 5-Lipoxygenase-Activating Protein Inhibitor, AM679, Reduces Inflammation in the Respiratory Syncytial Virus-Infected Mouse Eye", CLINICAL AND VACCINE IMMUNOLOGY, vol. 16, no. 11, 1 November 2009 (2009-11-01), pages 1654 - 1659, XP055107558, ISSN: 1556-6811, DOI: 10.1128/CVI.00220-09
TAO OUYANG ET AL: "Using siRNA technique to analyze the role of 5-lipoxygenase activating protein in highly purified glomerular endothelial cells", ZHONGGUO ZUZHI GONGCHENG YU LINCHUANG KANGFU= JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH, vol. 12, no. 2, 8 January 2008 (2008-01-08), CN, pages 283 - 288, XP055107522, ISSN: 1673-8225
TAO OUYANG ET AL: "Using siRNA technique to analyze the role of 5-lipoxygenase activating protein in highly purified glomerular endothelial cells", ZHONGGUO ZUZHI GONGCHENG YU LINCHUANG KANGFU= JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH, vol. 12, no. 2, 8 January 2008 (2008-01-08), CN, pages 283 - 288, XP055107522, ISSN: 1673-8225
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