Title:
SITE SPECIFIC NOTCH-ACTIVATING MOLECULE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/004761
Kind Code:
A1
Abstract:
The present invention relates to Notch receptor-targeting multispecific antigen-binding molecules, uses thereof, etc. The present invention provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety which specifically binds to a Notch receptor on a first target cell, and a second antigen-binding moiety which specifically binds to an anchor antigen on a second target cell. Furthermore, the inventors demonstrate anchorage-dependent Notch signalling activation by the multispecific antigen-binding molecules of the invention.
Inventors:
WEE ZHEN NING (SG)
RUIKE YOSHINAO (JP)
MURAMATSU HIROYASU (JP)
IGAWA TOMOYUKI (JP)
RUIKE YOSHINAO (JP)
MURAMATSU HIROYASU (JP)
IGAWA TOMOYUKI (JP)
Application Number:
PCT/JP2021/024655
Publication Date:
January 06, 2022
Filing Date:
June 30, 2021
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/13
Domestic Patent References:
| WO2002024221A2 | 2002-03-28 | |||
| WO2008051797A2 | 2008-05-02 | |||
| WO2021021825A1 | 2021-02-04 |
Foreign References:
| JP2012056934A | 2012-03-22 | |||
| JP2013231018A | 2013-11-14 | |||
| US20140093496A1 | 2014-04-03 |
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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