Title:
SITOSTEROLEMIA SUSCEPTIBILITY GENE (SSG): COMPOSITIONS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2001079272
Kind Code:
A3
Abstract:
The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of SSG.
Inventors:
TIAN HUI (US)
SCHULTZ JOSHUA (US)
SHAN BEI (US)
SCHULTZ JOSHUA (US)
SHAN BEI (US)
Application Number:
PCT/US2001/012758
Publication Date:
August 29, 2002
Filing Date:
April 18, 2001
Export Citation:
Assignee:
TULARIK INC (US)
TIAN HUI (US)
SCHULTZ JOSHUA (US)
SHAN BEI (US)
TIAN HUI (US)
SCHULTZ JOSHUA (US)
SHAN BEI (US)
International Classes:
C07K14/705; C12N15/12; (IPC1-7): C12N15/12; A61K38/00; C07K14/705; C07K16/18; G01N33/50
Domestic Patent References:
| WO2000058473A2 | 2000-10-05 |
Other References:
DATABASE EM_HUM EMBL Heidelberg, Germany; 5 October 1999 (1999-10-05), SULSTON J E ET AL.: "Homo sapiens BAC clone RP11-489K22", XP002186801
DATABASE EM_EST EMBL Heidelberg, Germany; 11 March 1997 (1997-03-11), MARRA M ET AL.: "The WashU-HHMI mouse EST project", XP002186802
DATABASE EM_EST EMBL Heidelberg, Germany; 6 March 1997 (1997-03-06), MARRA M ET AL.: "The WashU-HHMI mouse EST project", XP002186803
DATABASE SWALL EMBL Heidelberg, Germany; 1 November 1997 (1997-11-01), TZERMIA M ET AL.: "Probable ATP-dependent transporter YOL074C/YOL075C", XP002186804
PATEL S B ET AL: "Mapping a gene involved in regulating dietary cholesterol absorption: The sitosterolemia locus is found at chromosome 2p21.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 5, pages 1041 - 1044, XP002186798, ISSN: 0021-9738
KLUCKEN J ET AL: "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 2, 18 January 2000 (2000-01-18), Jan. 18, 2000, pages 817 - 822, XP002186799, ISSN: 0027-8424
LEE MI-HYE ET AL: "Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.", NATURE GENETICS, vol. 27, no. 1, January 2001 (2001-01-01), pages 79 - 83, XP002186800, ISSN: 1061-4036
DATABASE EM_EST EMBL Heidelberg, Germany; 11 March 1997 (1997-03-11), MARRA M ET AL.: "The WashU-HHMI mouse EST project", XP002186802
DATABASE EM_EST EMBL Heidelberg, Germany; 6 March 1997 (1997-03-06), MARRA M ET AL.: "The WashU-HHMI mouse EST project", XP002186803
DATABASE SWALL EMBL Heidelberg, Germany; 1 November 1997 (1997-11-01), TZERMIA M ET AL.: "Probable ATP-dependent transporter YOL074C/YOL075C", XP002186804
PATEL S B ET AL: "Mapping a gene involved in regulating dietary cholesterol absorption: The sitosterolemia locus is found at chromosome 2p21.", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 5, pages 1041 - 1044, XP002186798, ISSN: 0021-9738
KLUCKEN J ET AL: "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 2, 18 January 2000 (2000-01-18), Jan. 18, 2000, pages 817 - 822, XP002186799, ISSN: 0027-8424
LEE MI-HYE ET AL: "Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption.", NATURE GENETICS, vol. 27, no. 1, January 2001 (2001-01-01), pages 79 - 83, XP002186800, ISSN: 1061-4036
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