Title:
SKIN DISEASE MODEL MICE, FEED FOR CONSTRUCTING THE SAME AND METHOD OF EVALUATING TEST SUBSTANCE WITH THE USE OF THE MICE
Document Type and Number:
WIPO Patent Application WO/2002/074077
Kind Code:
A1
Abstract:
Model mice of skin diseases and/or diseases in association with abnormality in immune index which have a hairless and thymic phenotype; a method of constructing these mice by feeding mice with a feed having a reduced magnesium content (optionally together with a reduced zinc content); and the above-described feed.
Inventors:
EIRO HIROAKI (JP)
KURAMOTO MASATO (JP)
HOSHINO MASAYUKI (JP)
KURAMOTO MASATO (JP)
HOSHINO MASAYUKI (JP)
Application Number:
PCT/JP2002/002465
Publication Date:
September 26, 2002
Filing Date:
March 15, 2002
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
EIRO HIROAKI (JP)
KURAMOTO MASATO (JP)
HOSHINO MASAYUKI (JP)
EIRO HIROAKI (JP)
KURAMOTO MASATO (JP)
HOSHINO MASAYUKI (JP)
International Classes:
A01K67/027; A23K1/18; G01N33/50; (IPC1-7): A01K67/00; A23K1/00; A23K1/18; G01N33/15; G01N33/48; G01N33/50
Other References:
NABE T. ET AL.: "Studies itching in toluene-2,4-diisocyanate (TDI)-induced experimental allergic dermatitis. VII. Development of an itching model in dra skin-hairless mice (art. P-257).", JPN. J. PHARMACOL., vol. 85, no. SUPPL. 1, 1 March 2001 (2001-03-01), pages 124P, XP002950732
HASEGAWA H. ET AL.: "Assessment of taste disorders in rats by simultaneous study of the two-bottle preference test and abnormal ingestive behavior", AURIS NASUS LARYNX, vol. 13, no. SUPPL. I, 1986, pages S33 - S41, XP002950733
HANADA K. ET AL.: "Superoxide anion in polymorphonuclear leukocytes of hairless rats suffering from magnesium-deficiency dermatitis", J. DERMATOL., vol. 16, no. 4, 1989, pages 270 - 275, XP002950734
BARBIER A. ET AL.: "Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs", AGENTS AND ACTIONS, vol. 17, no. 3/4, 1985, pages 352 - 354, XP002950735
HANADA K. ET AL.: "Inhibitory effect of the leukotriene B4 receptor antagonist against hypomagnesic diet-induced dermatitis in hairless rats", J. DERMATOL., vol. 19, no. 8, 1992, pages 456 - 460, XP002950736
BISSETT D.L. ET AL.: "An animal model of solar-aged skin: histological physical and visible changes in UV-irradiated hairless mouse skin", PHOTOCHEM. PHOTOBIOL., vol. 46, no. 3, 1987, pages 367-375 - 377 AND 378, XP002950737
BRITTON J. ET AL.: "Dietary magnesium, lung function, wheezing and airway hyper-reactivity in a random adult population sample", THE LANCET, vol. 344, no. 8919, 1994, pages 357 - 362, XP002950738
MATSUMOTO TADAHIKO ET AL.: "Soyo o yusuru hifu shikkan ni okeru seitainai kinzoku dotai no kensaku", NSHIBI HIFU, vol. 59, no. 1, 1997, pages 71 - 78, XP002950739
KIHEI YOSHIKO ET AL.: "Tahatsuchi ALS ni okeru kenkyo yoin no kento - tei CaMG shoku toyo mouse no hifu byohen", SHINKEI HENSEI SHIKKAN NI KANSURU KENKYUHAN 2000 YEARS KENKYU HOKOKUSHO, 7 November 2001 (2001-11-07), pages 29 - 31, XP002950740
HASEGAWA H. ET AL.: "Assessment of taste disorders in rats by simultaneous study of the two-bottle preference test and abnormal ingestive behavior", AURIS NASUS LARYNX, vol. 13, no. SUPPL. I, 1986, pages S33 - S41, XP002950733
HANADA K. ET AL.: "Superoxide anion in polymorphonuclear leukocytes of hairless rats suffering from magnesium-deficiency dermatitis", J. DERMATOL., vol. 16, no. 4, 1989, pages 270 - 275, XP002950734
BARBIER A. ET AL.: "Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs", AGENTS AND ACTIONS, vol. 17, no. 3/4, 1985, pages 352 - 354, XP002950735
HANADA K. ET AL.: "Inhibitory effect of the leukotriene B4 receptor antagonist against hypomagnesic diet-induced dermatitis in hairless rats", J. DERMATOL., vol. 19, no. 8, 1992, pages 456 - 460, XP002950736
BISSETT D.L. ET AL.: "An animal model of solar-aged skin: histological physical and visible changes in UV-irradiated hairless mouse skin", PHOTOCHEM. PHOTOBIOL., vol. 46, no. 3, 1987, pages 367-375 - 377 AND 378, XP002950737
BRITTON J. ET AL.: "Dietary magnesium, lung function, wheezing and airway hyper-reactivity in a random adult population sample", THE LANCET, vol. 344, no. 8919, 1994, pages 357 - 362, XP002950738
MATSUMOTO TADAHIKO ET AL.: "Soyo o yusuru hifu shikkan ni okeru seitainai kinzoku dotai no kensaku", NSHIBI HIFU, vol. 59, no. 1, 1997, pages 71 - 78, XP002950739
KIHEI YOSHIKO ET AL.: "Tahatsuchi ALS ni okeru kenkyo yoin no kento - tei CaMG shoku toyo mouse no hifu byohen", SHINKEI HENSEI SHIKKAN NI KANSURU KENKYUHAN 2000 YEARS KENKYU HOKOKUSHO, 7 November 2001 (2001-11-07), pages 29 - 31, XP002950740
Attorney, Agent or Firm:
Odajima, Heikichi (Akasaka 1-chome Minato-ku, Tokyo, JP)
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