Title:
SKIN ULCER PREVENTIVE CURATIVE AGENT CONTAINING HUMAN RECOMBINANT HGF
Document Type and Number:
WIPO Patent Application WO/2005/023287
Kind Code:
A1
Abstract:
A vascularization spur composition, incarnant composition and skin ulcer preventive curative composition, comprising a human recombinant HGF having five amino acid residues deleted in the first Kringle domain thereof. The provided compositions are useful as a drug capable of spurring granulation and vascularization and being effective in tissue restoration, especially as a skin ulcer preventive curative agent.
Inventors:
NAKAMURA TOSHIKAZU (JP)
YOSHIDA SAHO (JP)
MATSUMOTO KUNIO (JP)
ITAMI SATOSHI (JP)
YOSHIKAWA KUNIHIKO (JP)
YOSHIDA SAHO (JP)
MATSUMOTO KUNIO (JP)
ITAMI SATOSHI (JP)
YOSHIKAWA KUNIHIKO (JP)
Application Number:
PCT/JP2004/012361
Publication Date:
March 17, 2005
Filing Date:
August 27, 2004
Export Citation:
Assignee:
NAKAMURA TOSHIKAZU (JP)
KRINGLE PHARMA INC (JP)
YOSHIDA SAHO (JP)
MATSUMOTO KUNIO (JP)
ITAMI SATOSHI (JP)
YOSHIKAWA KUNIHIKO (JP)
KRINGLE PHARMA INC (JP)
YOSHIDA SAHO (JP)
MATSUMOTO KUNIO (JP)
ITAMI SATOSHI (JP)
YOSHIKAWA KUNIHIKO (JP)
International Classes:
A61K38/18; A61L26/00; A61P9/00; A61P17/02; A61P43/00; (IPC1-7): A61K38/18; A61K9/70; A61P17/02; A61P9/00; A61P43/00
Foreign References:
| US5821223A | 1998-10-13 | |||
| JPH07179356A | 1995-07-18 |
Other References:
TOYODA, M. ET AL: "Overexpression of hepacyte growth factor/scatter factor promotes vascularizatio n and granulation tissue formation in vivo", FEBS LETTER, vol. 509, 2001, pages 95 - 100, XP004329151
SEKI, T. ET AL: "Isolation and expression of cdna for different forms of hepatocyte growth factorfrom human leukocyte", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 172, no. 1, 1990, pages 321 - 327, XP002084490
See also references of EP 1661578A4
SEKI, T. ET AL: "Isolation and expression of cdna for different forms of hepatocyte growth factorfrom human leukocyte", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 172, no. 1, 1990, pages 321 - 327, XP002084490
See also references of EP 1661578A4
Attorney, Agent or Firm:
Iwatani, Ryo (1-31 Dojima 2-chome, Kita-k, Osaka-shi Osaka 03, JP)
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