Title:
SMALL LIPID NANOPARTICLES, AND CANCER VACCINE INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2021/085696
Kind Code:
A1
Abstract:
The present invention relates to small lipid nanoparticles, a small lipid nanoparticle (SLNP)-based nanovaccine platform including same, and a combination treatment regimen with an immune checkpoint inhibitor. Lipid nanoparticles according to the present invention can easily deliver antigens and anionic drugs into cells, and exhibit strong anti-tumor effects when loaded with tumor-associated antigens. Particularly, a cancer vaccine kit according to the present invention including lipid nanoparticles according to the present invention as a first vaccine composition and lipid nanoparticles and an immune checkpoint inhibitor as a second vaccine composition can be used to effectively suppress tumor regrowth and recurrence triggered by the occurrence of immunosuppression against a cancer nanovaccine.
Inventors:
JON SANG YONG (KR)
KIM YU JIN (KR)
KANG SUK MO (KR)
KIM YU JIN (KR)
KANG SUK MO (KR)
Application Number:
PCT/KR2019/014741
Publication Date:
May 06, 2021
Filing Date:
November 01, 2019
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K9/51; A61K39/00; A61K45/06; A61P35/00
Domestic Patent References:
| WO2013143555A1 | 2013-10-03 | |||
| WO2013039989A1 | 2013-03-21 | |||
| WO2016155809A1 | 2016-10-06 |
Other References:
LEE, J: "Mono-arginine cholesterol-based small lipid nanoparticles as a systemic siRNA delivery platform for effective cancer therapy", THERANOSTICS, vol. 6, no. 2, 2016, pages 192 - 203, XP055508674, DOI: 10.7150/thno.13657
ZHAO, H.: "The application of nanoparticle-based drug delivery systems in checkpoint blockade cancer immunotherapy", JOURNAL OF IMMUNOLOGY RESEARCH, vol. 3673295, 2018, pages 1 - 13, XP055924511, DOI: 10.1155/2018/3673295
ZHAO, H.: "The application of nanoparticle-based drug delivery systems in checkpoint blockade cancer immunotherapy", JOURNAL OF IMMUNOLOGY RESEARCH, vol. 3673295, 2018, pages 1 - 13, XP055924511, DOI: 10.1155/2018/3673295
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
Download PDF:
Previous Patent: SPATIAL IMAGE CLUSTER FOR VEHICLE
Next Patent: SIGNAL PROCESSING DEVICE AND IMAGE DISPLAY DEVICE COMPRISING SAME
Next Patent: SIGNAL PROCESSING DEVICE AND IMAGE DISPLAY DEVICE COMPRISING SAME