Title:
SMALL MOLECULE COMPOUND TARGETING BCL9/β-CATENIN INTERACTION
Document Type and Number:
WIPO Patent Application WO/2024/022521
Kind Code:
A1
Abstract:
Provided is a small molecule compound targeting BCL9/β-catenin interaction. Specifically, provided are a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound represented by formula I has excellent ability to inhibit BCL9/β-catenin interaction.
Inventors:
ZHU WENHUA (CN)
Application Number:
PCT/CN2023/110001
Publication Date:
February 01, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
NANTONG HUANJUTAI BIOTECH CO LTD (CN)
JIANGSU MINGSHENG JUTAI BIOTECHNOLOGY CO LTD (CN)
JIANGSU MINGSHENG JUTAI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D401/12; A61K31/445; A61P35/00; C07D211/00
Domestic Patent References:
| WO2021055936A1 | 2021-03-25 |
Foreign References:
| CN115583938A | 2023-01-10 | |||
| US20210380558A1 | 2021-12-09 | |||
| EP1780210A1 | 2007-05-02 | |||
| US20070191429A1 | 2007-08-16 | |||
| US20110118314A1 | 2011-05-19 | |||
| CN106458983A | 2017-02-22 | |||
| CN105228982A | 2016-01-06 | |||
| CN1717389A | 2006-01-04 |
Other References:
WANG, ZHEN ET AL.: "New ZW 4864 Derivatives as Small-Molecule Inhibitors for the -Catenin/ BCL9 Protein-Protein Interaction", ACS MEDICINAL CHEMISTRY LETTERS, vol. 13, 25 April 2022 (2022-04-25), pages 865 - 870, XP093020420, DOI: 10.1021/acsmedchemlett.2c00068
WANG, ZHEN ET AL.: "Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the (3- Catenin/B- Cell Lymphoma 9 Protein-Protein Interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, 12 August 2021 (2021-08-12), pages 12109 - 12131, XP093020418, DOI: 10.1021/acs.jmedchem.1c00742
WANG, ZHEN ET AL.: "Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the (3-Catenin/B- Cell Lymphoma 9 Protein- Protein Interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, 27 April 2021 (2021-04-27), pages 5886 - 5904, XP093065898, DOI: 10.1021/acs.jmedchem.1c00046
WANG, ZHEN ET AL.: "Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the (3- Catenin/B- Cell Lymphoma 9 Protein-Protein Interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, 12 August 2021 (2021-08-12), pages 12109 - 12131, XP093020418, DOI: 10.1021/acs.jmedchem.1c00742
WANG, ZHEN ET AL.: "Discovery of 2-(3-(3-Carbamoylpiperidin-1-yl)phenoxy)acetic Acid Derivatives as Novel Small-Molecule Inhibitors of the (3-Catenin/B- Cell Lymphoma 9 Protein- Protein Interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, 27 April 2021 (2021-04-27), pages 5886 - 5904, XP093065898, DOI: 10.1021/acs.jmedchem.1c00046
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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