Title:
SMALL MOLECULE COMPOUND TARGETING SRSF6 PROTEIN AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/077678
Kind Code:
A1
Abstract:
Disclosed in the present invention are a small molecule compound targeting an SRSF6 protein and a preparation method therefor and a use thereof. The compound is as represented by formula (I). A molecule can selectively inhibit abnormal cells having a high expression of SRSF6, thereby reducing the occurrence of abnormal alternative splicing events and inhibiting the occurrence and development of tumors, especially colorectal cancer, and can be used as a new drug candidate against colorectal cancer.
Inventors:
YU WENYING (CN)
LAI MAODE (CN)
WANG TONG (CN)
LI CONG (CN)
ZHANG HONGHE (CN)
LI ZHIYU (CN)
LAI MAODE (CN)
WANG TONG (CN)
LI CONG (CN)
ZHANG HONGHE (CN)
LI ZHIYU (CN)
Application Number:
PCT/CN2022/072519
Publication Date:
May 11, 2023
Filing Date:
January 18, 2022
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D215/26; A61K31/4704; A61P35/00; C07D401/10; C07D401/12; C07D417/12
Domestic Patent References:
| WO2021003161A1 | 2021-01-07 |
Foreign References:
| CN107021921A | 2017-08-08 | |||
| CN1353692A | 2002-06-12 | |||
| CN1798559A | 2006-07-05 | |||
| CN107582550A | 2018-01-16 | |||
| CN110013481A | 2019-07-16 |
Other References:
BAUR, FRANCOIS ET AL.: "The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 9, 19 April 2010 (2010-04-19), pages 3675 - 3684, XP055121338, ISSN: 1520-4804, DOI: 10.1021/jm100068m
DATABASE Registry 11 June 2008 (2008-06-11), ANONYMOUS : "2(1H)-Quinolinone, 5-[(1 S)-2-[(2,3-dihydro-1 H-inden-2-yl)amino]- 1- hydroxyethyl]-8-(ph enylmethoxy)-", XP093064765, retrieved from CAS Database accession no. 1027305-45-8
"Master's Thesis", 1 May 2017, TIANJIN MEDICAL UNIVERSITY, CN, article CHU, XIAOQIN: "Study on Synthesis Process of Indacaterol Maleate", pages: 1 - 80, XP009545533
DATABASE Registry 11 June 2008 (2008-06-11), ANONYMOUS : "2(1H)-Quinolinone, 5-[(1 S)-2-[(2,3-dihydro-1 H-inden-2-yl)amino]- 1- hydroxyethyl]-8-(ph enylmethoxy)-", XP093064765, retrieved from CAS Database accession no. 1027305-45-8
"Master's Thesis", 1 May 2017, TIANJIN MEDICAL UNIVERSITY, CN, article CHU, XIAOQIN: "Study on Synthesis Process of Indacaterol Maleate", pages: 1 - 80, XP009545533
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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