Title:
SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
Document Type and Number:
WIPO Patent Application WO/2022/056369
Kind Code:
A3
Abstract:
Described herein are compounds and compositions for use in treatment or prevention of an inflammatory bowel disease, gastrointestinal cancer, or a systemic bacterial infection in a subject in need thereof. The subject may be colonized by one or more pathogenic bacterial strains such as B. fragilis, E. faecalis, or C. perfringens. In certain aspects, the disclosure provides a method of diminishing the pathogenic effects of these bacterial strains by administering a compound that binds to and/or inhibits one or more toxins produced thereby.
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Inventors:
HOEKSTRA WILLIAM (US)
RYU HYUNJI (US)
CHINTHA PRIYANKA (US)
RYU HYUNJI (US)
CHINTHA PRIYANKA (US)
Application Number:
PCT/US2021/050048
Publication Date:
April 21, 2022
Filing Date:
September 13, 2021
Export Citation:
Assignee:
ARTIZAN BIOSCIENCES INC (US)
International Classes:
A61K39/07; A61K39/40; A61P1/00; C07K16/12
Domestic Patent References:
| WO2020010254A1 | 2020-01-09 |
Foreign References:
| US9181181B2 | 2015-11-10 |
Other References:
DATABASE PUBCHEM SUBSTANCE 5 January 2010 (2010-01-05), ANONYMOUS : "SUBSTANCE RECORD SID 86982774", XP055934600, Database accession no. SID 86982774
DATABASE PubChem SUBSTANCE 5 January 2010 (2010-01-05), ANONYMOUS : "SUBSTANCE RECORD SID 86689948", XP055934605, Database accession no. SID 86689948
DATABASE PubChem SUBSTANCE NCBI; 28 January 2016 (2016-01-28), ANONYMOUS : "SUBSTANCE RECORD SID 302966353", XP055934607, Database accession no. SID 302966353
DATABASE PubChem SUBSTANCE 5 January 2010 (2010-01-05), ANONYMOUS : "SUBSTANCE RECORD SID 86689948", XP055934605, Database accession no. SID 86689948
DATABASE PubChem SUBSTANCE NCBI; 28 January 2016 (2016-01-28), ANONYMOUS : "SUBSTANCE RECORD SID 302966353", XP055934607, Database accession no. SID 302966353
Attorney, Agent or Firm:
TUSCAN, Michael, S. et al. (US)
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