SMALL-MOLECULE INHIBITORS OF INTERLEUKIN-2 - SUNESIS PHARMACEUTICALS INC

Title:

SMALL-MOLECULE INHIBITORS OF INTERLEUKIN-2

Document Type and Number:

WIPO Patent Application WO2003051797

Kind Code:

A3

Abstract:

Compounds of formulae I and I', methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of Il-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.

Inventors:

ARKIN MICHELLE R
MCDOWELL ROBERT S
OSLOB JOHAN D
RAIMUNDO BRIAN C
WAAL NATHAN D
YU CHUL HYUN

Application Number:

PCT/US2002/040430

Publication Date:

January 15, 2004

Filing Date:

December 17, 2002

Export Citation:

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Assignee:

SUNESIS PHARMACEUTICALS INC (US)

International Classes:

C07K5/06; C07K5/065; C07K5/078; A61K38/00; (IPC1-7): C07D401/04; A61K31/4155; C07D401/14; C07D403/04

Domestic Patent References:

WO1996032938A1

1996-10-24

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