Claims

1. A compound of formula (I):

, wherein X² is CR² or N;

X³ is CR³ or N;

X⁶ is C=O, or CR⁷R⁸; the or each Z is independently CR⁹R¹⁰ or NR⁹;

X⁷ is S, SO, SO₂, O, NR¹¹ or CR¹¹R¹²; n is o, l or 2; wherein, when n is l and Z is CR⁹R¹⁰; then X⁷ is S, SO, SO₂, O or NR¹¹; and when n is 1 and Z is NR⁹ then X⁷ is CR¹¹R¹²; R¹, R⁴, and R⁸ are each independently selected from the group consisting of H, halogen,

OH, CN, COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁-C₆ alkyl, optionally substituted C₁-C₆ alkylsulfonyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted C₁-C₆ alkoxy, optionally substituted C₁-C₆ alkoxycarbonyl group, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted mono or bicyclic 3 to 8 membered heterocycle, optionally substituted aryloxy, optionally substituted heteroaryloxy and optionally substituted heterocyclyloxy;

R⁹, R¹⁰, R¹¹ andR¹² are each independently selected from the group consisting of H, halogen, OH, CN, COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁- C₆ alkyl, optionally substituted C₂-C₆ alkenyl and optionally substituted C₂-C₆ alkynyl; one of R² and R³ is -L¹-L²-L³-L⁴-R¹⁵ and, when X² is CR² and X³ is CR³, the other of R² and R³ is selected from the group consisting of H, halogen, OH, CN, COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁-C₆ alkyl, optionally substituted C₁-C₆ alkylsulfonyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted C₁-C₆ alkoxy, optionally substituted C₁-C₆ alkoxycarbonyl group, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted mono or bicyclic 3 to 8 membered heterocycle, optionally substituted aryloxy and optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy; R⁵ and R⁷ are selected from the group consisting of H, halogen, OH, CN, COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁-C₆ alkyl, optionally substituted C₁-C₆ alkylsulfonyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted C₁-C₆ alkoxy, optionally substituted C₁-C₆ alkoxycarbonyl group, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted mono or bicyclic 3 to 8 membered heterocycle, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclyloxy and L³-L⁶-R¹⁶; wherein a maximum of one of R⁵ and R⁷ is -L⁵-L⁶-R¹⁶; R¹³ and R¹⁴ are each independently selected from the group consisting of H, halogen,

OH, CN, COOH, CONH₂, NH₂, NHCOH, optionally substituted C₁-C₆ alkyl, optionally substituted C₁-C₆ alkylsulfonyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted C₁-C₆ alkoxy, optionally substituted C₁-C₆ alkoxycarbonyl group, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, optionally substituted mono or bicyclic 3 to 8 membered heterocycle, optionally substituted aryloxy, optionally substituted heteroaryloxy and optionally substituted heterocyclyloxy; a) L¹ is NR¹⁷ or O, L² is C=O, C=S, C=NR¹⁹ or SO₂, and L³ is absent, NR¹⁸ or O; b) L¹ is absent, L² is C=O, C=S, C=NR¹⁹ or SO₂, and L³ is NR¹⁸ or O and when L² is C=O, L³ is not NR¹⁸; c) L¹ is absent or is a C₁-C₃ alkylene; L² is absent; and L³ is O; or d) L¹ is a C₅-C₆ cycloalkylene, a C₆ arylene, a 5 membered heteroarylene or a 5 to 6 membered heterocyclylene; L² is absent and L³ is absent; L⁴ is absent or is an optionally substituted C₁-C₆ alkylene, an optionally substituted C₂- C₆ alkenylene, an optionally substituted C₂-C₆ alkynylene, an optionally substituted C₃- C₆ cycloalkylene, an optionally substituted C₆-C₁₂ arylene, an optionally substituted 5 to 10 membered heteroarylene or an optionally substituted 3 to 8 membered heterocyclylene; L³ is absent or an optionally substituted C₁-C₆ alkylene, an optionally substituted C₂-C₆ alkenylene, an optionally substituted C₂-C₆ alkynylene, O, S, S=O, SO₂ or NR¹⁹; L⁶ is absent or an optionally substituted C₁-C₆ alkylene, an optionally substituted C₂-C₆ alkenylene, an optionally substituted C₂-C₆ alkynylene, O, S, S=O, SO₂ or NR¹⁹;

R¹⁵ is H, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl or optionally substituted mono or bicyclic 3 to 8 membered heterocycle, wherein when R¹⁵ is an optionally substituted aryl the aryl is unsubstituted or substituted with one or more substituents selected from the group consisting of optionally substituted C₁-C₆ alkyl, halogen, OH, oxo, OP(O)(OR²⁰)(OR²¹), optionally substituted C₁-C₆ alkoxy, NR²⁰R²¹, CONR²⁰R²¹, CN,

C(O)R²⁰, COOR²⁰, NO₂, azido, SO₂R²⁰, C(O)R²⁰ and NR²⁰COR²¹ and when R¹⁵ is an optionally substituted heteroaryl, an optionally cycloalkyl or an optionally substituted heterocycle the heteroaryl, cycloalkyl or heterocycle is unsubstituted or substituted with one or more substituents selected from the group consisting of optionally substituted C₁-C₆ alkyl, halogen, OH, oxo, OP(O)(OR²⁰)(OR²¹), optionally substituted C₁-C₆ alkoxy,

NR²⁰R²¹, CONR²⁰R²¹, CN, C(O)R²⁰, COOR²⁰, NO₂, azido, SO₂R²⁰, C(O)R²⁰ and NR²⁰COR²¹;

R¹⁶ is H, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl or optionally substituted mono or bicyclic 3 to 8 membered heterocycle; and R¹⁷ to R¹⁹ are independently H, an optionally substituted C₁-C₆ alkyl, an optionally substituted C₂-C₆ alkenyl, an optionally substituted C₂-C₆ alkynyl or CN; or a pharmaceutically acceptable complex, salt, solvate, tautomeric form or polymorphic form thereof.

2. The compound of claim 1, wherein X² is CR² and X³ is CR³.

3. The compound of either claim 1 or claim 2, wherein R¹ and R⁴ are independently H, halogen, OH, CN, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl.

4. The compound of any preceding claim, wherein X² is CR² and X³ is CR³, and one of R² and R³ is -L¹-L²-L³-L⁴-R¹⁵ and the other of R² and R³ is H, halogen, OH, CN, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl.

5. The compound of any preceding claim, wherein;

L¹ is NR¹⁷, L² is C=O, C=S, C=NR¹⁹ or SO₂ and L³ is absent or is NR¹⁸; or L¹ is absent, L² is C=S, C=NR¹⁹ or SO₂ and L³ is NR¹⁸.

6. The compound of any one of claims 1 to 4, wherein L¹ is absent or a C₁-C₃ alkylene, L² is absent and L³ is O. 7. The compound of any one of claims 1 to 4, wherein L¹ is an optionally substituted C₅-C₆ cycloalkylene, an optionally substituted C₆ arylene, an optionally substituted 5 membered heteroarylene or an optionally substituted 5 or 6 membered heterocyclylene, L² is absent and L³ is absent.

8. The compound of any preceding claim, wherein -L¹- L²-L³- are absent, R¹³. 9. The compound of any preceding claim, wherein L³ is absent, an optionally substituted C₁-C₆ alkylene, an optionally substituted C₂-C₆ alkenylene or an optionally substituted C₂-C₆ alkynylene.

10. The compound of any one of claims 1 to 9, wherein L⁴ is an optionally substituted C₃-C₆ cycloalkylene, an optionally substituted C₆-C₁₂ arylene, an optionally substituted 5 to 10 membered heteroarylene or an optionally substituted 3 to 8 membered heterocyclylene. li. The compound of any preceding claim, wherein -L¹-L²-L³-L⁴- is -OCH₂CH₂-*, where an asterisk indicates the point of bonding to R¹⁵.

12. The compound of any preceding claim, wherein R¹⁷ and R¹⁸ are independently H, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl and R¹⁹ is H, C₁-C₃ alkyl, C₂-C₃ alkenyl or C₂-C₃ alkynyl.

13. The compound of any preceding claim, wherein R¹⁵ is a mono or bicyclic C₆-C₁₂ aryl and the aryl is unsubstituted or substituted with one or more substituents selected from the group consisting of optionally substituted C₁-C₆ alkyl, halogen, OH, oxo, OP(O)(OR²⁰)(OR²¹), optionally substituted C₁-C₆ alkoxy, NR²⁰R²¹, CONR²⁰R²¹, CN, C(O)R²⁰, COOR²⁰, NO₂, azido, SO₂R²⁰, C(O)R²⁰ and NR²⁰COR²¹.

14. The compound of any one of claims 1 to 12, wherein R¹⁵ is a mono or bicyclic optionally substituted 5 to 10 membered heteroaryl, an optionally substituted C₃-C₆ cycloalkyl or an optionally substituted 3 to 8 membered heterocycle, and the heteroaryl, cycloalkyl or heterocycle is unsubstituted or substituted with one or more substituents selected from the group consisting of optionally substituted C₁-C₆ alkyl, halogen, OH, oxo, OP(O)(OR²⁰)(OR²¹), optionally substituted C₁-C₆ alkoxy, NR²⁰R²¹, CONR²⁰R²¹, CN, C(O)R²⁰, COOR²⁰, NO₂, azido, SO₂R²⁰, C(O)R²⁰ and NR²⁰COR²¹. 15. The compound of any preceding claim, wherein R¹⁵ is

16. The compound of any preceding claim, wherein R⁵ is -L⁵-L⁶-R¹⁶. 17. The compound of claim 16, wherein L⁵ is absent, an optionally substituted C₁-C₃ alkylene, an optionally substituted C₂-C₃ alkenylene or an optionally substituted C₂-C₃ alkynylene.

18. The compound of claim 17, wherein L⁵ is CH₂, CH₂CH₂, CO absent.

19. The compound of any one of claims 16 to 18, wherein L⁶ is absent, O, S, S=O, SO₂ or NR¹⁹.

20. The compound of any one of claims 16 to 19, wherein R¹⁶ is optionally substituted mono or bicyclic C₃-C₆ cycloalkyl, mono or bicyclic optionally substituted C₆-C₁₂ aryl, mono or bicyclic optionally substituted 5 to 10 membered heteroaryl or optionally substituted mono or bicyclic 3 to 8 membered heterocycle.

21. The compound of claim 20, wherein the cycloalkyl, aryl, heteroaryl or heterocycle is unsubstituted or substituted with one or more substituents selected from the group consisting of optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl, optionally substituted C₂-C₆ alkynyl, optionally substituted C₁-C₆ alkoxy, halogen, OH, CN, oxo, C(O)R²⁰, COOR²⁰, 0C(O)R²⁰, CONR²⁰R²¹, NR²⁰R²¹, NR²⁰C(O)R²¹, =NOR²⁰, SR²⁰, SO R²⁰, OSO R²⁰, SO₂NR²⁰R²¹, OP(O)(OR²⁰)(OR²¹), optionally substituted C₆-C₁₂ aryl, optionally substituted 5 to 10 membered heteroaryl, optionally substituted C₃-C₆ cycloalkyl and optionally substituted 3 to 8 membered heterocycle.

22. The compound of claim 20 or 21, wherein R¹⁶ is cyclopropyl, cyclopentyl,

23. The compound of any one of claims 1 to 15, wherein R⁵ is H, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl. 24- The compound of any preceding claim, wherein R⁷ and R⁸ are independently H, halogen, OH, CN, COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁- C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl.

25. The compound of any preceding claim, wherein n is 1.

26. The compound of claim 25, wherein Z is CR⁹R¹⁰ and X⁷ is S, SO, SO₂, O or NR¹¹. 27. The compound of claim 26, wherein R⁹ and R¹⁰ are H, halogen, OH, CN,

COOR¹³, CONR¹³R¹⁴, NR¹³R¹⁴, NR¹³COR¹⁴, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl and R¹³ and R¹⁴ are H, optionally substituted C₁-C₃ alkyl, optionally substituted C₂-C₃ alkenyl or optionally substituted C₂-C₃ alkynyl.

28. The compound of either claims 26 or claim 27, wherein X⁷ is S or O.

29. The compound of claim 25, wherein Z is NR⁹ and X⁷ is CR¹¹R¹². 30. The compound of claim 29, wherein R⁹ is H, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl and R¹¹ and R¹² are independently H, halogen, OH, CN, optionally substituted C₁-C₆ alkyl, optionally substituted C₂-C₆ alkenyl or optionally substituted C₂-C₆ alkynyl. 31. The compound of any one of claims 1 to 24, wherein n is o.

32. The compound of any preceding claim, wherein the compound is a compound of formula (II) or (III): 33- The compound of any preceding claim 32, wherein the compound is a compound of formula (Ila), (lIb), (IlIa) or (IIIb):

34. The compound of claim 1, wherein the compound is:

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-phenylurea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(4-fluorophenyl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(pyridin-3-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(pyridin-4-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-5-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(4-cyanobenzyl)urea;

1-(4-Fluorophenyl)-3-(3-oxo-4-(pyridin-3-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]thiazin-6-yl)urea;

1-(4-Fluorophenyl)-3-(3-oxo-4-(pyridin-4-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]thiazin-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-3-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-7-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)urea;

1-(4-(Benzo[d]isoxazol-3-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)- 3-(1H-indol-6-yl)urea;

1-(3-Aminophenyl)-3-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea;

1-(4-Fluorophenyl)-3-(4-(imidazo[1,2-a]pyridin-2-ylmethyl)-3-oxo-3,4-dihydro-2H- benzo [b] [1,4]thiazin-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1-methyl-1H-indol-6- yl)urea; 1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indazol-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(2-oxo-1, 2,3,4- tetrahydroquinolin-7-yl)urea;

1-(1H-Benzo[d]imidazol-6-yl)-3-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin- 6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6-yl)-1- methylurea;

1-(4-Benzyl-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-phenylurea; 4-(3-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)ureido)benzamide; (S)-1-(1-Benzyl-3,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl)-3-(4- fluorophenyl)urea;

1-(1-Benzyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl)-3-(4-fluorophenyl)urea;

1-(1-Benzyl-3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl)-3-(1H-indol-6-yl)urea ex 40; 4-(2-Chloro-6-fluorobenzyl)-6-(4-fluorophenethoxy)-2H-benzo[b][1,4]thiazin-3(4H)- one;

4-(2-Chloro-6-fluorobenzyl)-6-(((4-fluorobenzyl)oxy)methyl)-2H-benzo[b][1,4]thiazin-

3(4H)-one;

4-(2-Chloro-6-fluorobenzyl)-6-(5-phenyl-1H-imidazol-2-yl)-2H-benzo[b][1,4]thiazin- 3(4H)-one;

4-(2-Chloro-6-fluorobenzyl)-6-(5-phenyl-1H-1,2,4-triazol-3-yl)-2H- benzo[b][1,4]thiazin-3(4H)-one;

6-(5-Benzyl-4H-1,2,4-triazol-3-yl)-4-(2-chloro-6-fluorobenzyl)-2H- benzo[b][1,4]thiazin-3(4H)-one; 4-(2-Chloro-6-fluorobenzyl)-6-(4-phenyloxazol-2-yl)-2H-benzo[b][1,4]thiazin-3(4H)- one;

N-(4-Benzyl-3-oxo-3,4-dihydro2H-benzo[b][1,4]thiazin-6-yl)-2-(1H-indol-6- yl)acetamide;

N-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-2-(furan-2- yl)acetamide;

4-Benzoyl-N-(furan-2-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-sulfonamide;

1-(4-Benzyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(3,4-dihydro-2H- benzo [b] [1,4]oxazin-6-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-3-(4-fluorophenyl)urea; 1-(4-(3-aminobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6- yl)urea;

3-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-1-(1H-indol-6-yl)-1- methylurea;

1-(1H-indol-6-yl)-3-(4-((2-methylpyridin-4-yl)methyl)-3-oxo-3,4-dihydro-2H- benzo [b] [1,4]thiazin-6-yl)urea;

1-(1H-indol-6-yl)-3-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)urea;

1-(4-(2-chloro-6-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-3- (1H-indol-6-yl)urea;

1-(4-benzyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(5-methyl-1H-indol-6- yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(2-methyl-1H-indol-6- yl)urea;

1-(4-(2-chloro-6-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(2-chloro-4-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(2,3-difluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(2,6-difluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

3-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)benzamide;

1-(4-(3-chloro-5-(trifluoromethyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin- 7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(2-(2-chlorophenoxy)ethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(4-([1,1'-biphenyl]-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(4-(3-chloro-5-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea; 1-(4-((6-chlorobenzo[d][1,3]dioxol-5-yl)methyl)-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)-3,4-dihydro-

2H-benzo[b][1,4]oxazin-7-yl)urea;

1-(4-(3,5-difluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(4-((trifluoromethyl)thio)benzyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-(3-chloro-4-(trifluoromethoxy)benzyl)-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(4-fluoro-3-methylbenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(4-(4-(difluoromethoxy)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(4-(2-chlorophenethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(3-chloro-4-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(3-fluoro-5-(trifluoromethyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin- 7-yl)-3-(1H-indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(2-(trifluoromethyl)benzyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7- yl)-3-(1H-indol-6-yl)urea;

1-(4-(2,5-dimethoxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(4-(3-cyanobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6- yl)urea;

1-(4-(benzo[d]thiazol-2-ylmethyl)-3-oxo-3,4-dihydro2H-benzo[b][1,4]oxazin-7-yl)-3- (1H-indol-6-yl)urea;

6-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)nicotinic acid;

1-(4-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(4-cyano-2-fluorobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea; 1-(1H-indol-6-yl)-3-(3-oxo-4-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-(4-chloro-2-(methylsulfonyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-

7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6- yl)urea;

1-(4-(2-chloro-6-fluoro-3-methoxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-

7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(2-chloro-6-fluoro-3-hydroxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin- 7-yl)-3-(1H-indol-6-yl)urea;

1-(4-(2,6-difluoro-4-methoxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-

3-(1H-indol-6-yl)urea;

1-(4-(2,6-difluoro-4-hydroxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-

3-(1H-indol-6-yl)urea;

1-(4-(4-(1H-1,2,4-triazol-1-yl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)- 3-(1H-indol-6-yl)urea;

1-(4-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-

7-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(furan-2- ylmethyl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(3-(4-chlorophenyl)- 1H-pyrazol-4-yl)urea;

1-((1H-pyrrol-3-yl)methyl)-3-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7- yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(5, 6,7,8- tetrahydronaphthalen-2-yl)urea;

1-(4-((5-(tert-butyl)-1,2,4-oxadiazol-3-yl)methyl)-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(i, 2,3,4- tetrahydronaphthalen-2-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(2,3-dihydro-1H-inden-

2-yl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(4- phenylcyclohexyl)urea;

1-(4-benzyl-3-oxo-3,4-dihydro2H-benzo[b][1,4]oxazin-7-yl)-3-(1-phenyl-1H-pyrazol-

3-yl)urea; 1-(4-(4-hydroxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-

6-yl)urea; methyl 2-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)benzoate; N-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3,4-dihydroisoquinoline- 2(1H)-carboxamide;

1-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(indolin-6-yl)urea;

2-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)benzoic acid; 2-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)benzamide;

1-(4-((i,4-dioxan-2-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H- indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-((tetrahydrofuran-2-yl)methyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(pyridin-4-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(pyridin-3-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(pyridin-2-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-((tetrahydrofuran-3-yl)methyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-((1,3,4-oxadiazol-2-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3- (1H-indol-6-yl)urea;

1-(4-(3-hydroxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-

6-yl)urea;

1-(4-(4-(hydroxymethyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(pyrazin-2-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

3-((7-(3-(1H-indol-6-yl)ureido)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4- yl)methyl)benzamide;

1-(4-(3-(hydroxymethyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3- (1H-indol-6-yl)urea; 1-(4-(cyanomethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6- yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-((2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-(2-hydroxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-

6-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-(pyrimidin-4-ylmethyl)-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

1-(4-((1H-pyrazol-5-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3- (1H-indol-6-yl)urea;

1-(4-((1H-imidazol-5-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(4-((i,2,4-oxadiazol-5-yl)methyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-

(1H-indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(4-(isoxazol-3-ylmethyl)-3-oxo-3,4-dihydro-2H- benzo [b] [1,4]oxazin-7-yl)urea;

7-(3-(1H-indol-6-yl)ureido)-4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6- carboxamide;

1-(4-benzyl-6-bromo-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6- yl)urea;

1-(4-fluorophenyl)-3-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea;

2-amino-N-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-7,8- dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide;

1-(1H-indol-6-yl)-3-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea; N-(4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-1H-indole-6- carboxamide;

1-(4-Benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzoyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-3-yl)urea;

1-(4-(cyclopropylmethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6- yl)urea;

1-(1H-indol-6-yl)-3-(4-(pyridin-4-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6- yl)urea; 1-(4-(cyclopentylmethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6- yl)urea;

1-(1H-indol-6-yl)-3-(4-(2-(pyrrolidin-1-yl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-

6-yl)urea;

1-(4-benzyl-1-oxido-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(1H-indol-6-yl)-3-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea;

1-(4-(2-chloro-6-fluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol- 6-yl)urea;

1-(4-(2-chloro-6-fluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol- 6-yl)urea;

1-(4-(2-chloro-6-fluorobenzyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)-3-(1H-indol-

6-yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-pyrrolo[2,3-b]pyridin-6- yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(4-fluorophenyl)urea;

1-(4-(2-fluoro-4-(trifluoromethoxy)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-

3-(1H-indol-6-yl)urea;

4-benzyl-N-(1H-indol-6-ylsulfamoyl)-2,3-dihydro-1,4-benzoxazin-6-amine

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-pyrrolo[3,2-b]pyridin-6- yl)urea;

1-(4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-6-yl)-1-methylurea;

6-(3-(1H-indol-6-yl)ureido)-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7- carboxamide;

1-(4-benzyl-7-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(1H-Indol-6-yl)-3-(4-phenyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)urea;

1-(1H-Indol-6-yl)-3-(3-oxo-4-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)urea; N-1H-indol-6-yl-N'-(4-phenyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)sulfuric diamide

1-(1H-indol-6-yl)-3-(4-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(4-phenyl-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)urea;

1-(1H-indol-6-yl)-3-(3-oxo-4-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)urea;

1-(1H-indol-6-yl)-3-(4-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)urea;

1-(1H-indol-6-yl)-3-(4-(oxazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)urea;

1-(4-Benzyl-1-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl)-3-(1H-indol-6-yl)urea;

1-(1-Benzylindolin-6-yl)-3-(1H-indol-6-yl)urea; 2-(6-(3-(1H-Indol-6-yl)ureido)-4-benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-

2-yl)acetamide; 1-(3-Allyl-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(4-Benzyl-3-(2,3-dihydroxypropyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H- indol-6-yl)urea;

1-(4-Benzyl-3-(2-hydroxyethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H- indol-6-yl)urea;

1-(4-Benzyl-3-cyano-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-6-yl)urea;

1-(3-(Aminomethyl)-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H-indol-

6-yl)urea;

6-(3-(1H-Indol-6-yl)ureido)-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-3- carboxamide;

1-(4-benzyl-3-cyano-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-6-yl)urea;

1-(3-(aminomethyl)-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-indol-

6-yl)urea;

7-(3-(1H-indol-6-yl)ureido)-4-benzyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-3- carboxamide;

2-(6-(3-(1H-Indol-6-yl)ureido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-2- phenylacetamide;

1-(4-(2-Hydroxy-1-phenylethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-3-(1H- indol-6-yl)urea; Methyl 2-(6-(3-(1H-indol-6-yl)ureido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-2- phenylacetate;

2-(6-(3-(1H-indol-6-yl)ureido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N-methyl-2- phenylacetamide;

2-(6-(3-(1H-indol-6-yl)ureido)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N- cyclopropyl-2-phenylacetamide;

6-(4-(1H-Indol-6-yl)piperazin-1-yl)-4-benzyl-2H-benzo[b][1,4]thiazin-3(4H)-one;

1-(4-Benzyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-2-cyano-3-(1H-indol-6- yl)guanidine; or

1-(4-Benzyl-2-(cyanomethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)-3-(1H- indol-6-yl)urea.

35. A pharmaceutical composition comprising a compound according to any preceding claim, or a pharmaceutically acceptable salt, solvate, tautomeric form or polymorphic form thereof, and a pharmaceutically acceptable vehicle.

36. A compound, as defined in any one of claims 1 to 34, or a pharmaceutically acceptable complex, salt, solvate, tautomeric form or polymorphic form thereof, of a pharmaceutical composition, as defined by claim 35, for use as a medicament. 37. A compound, as defined in any one of claims 1 to 34, or a pharmaceutically acceptable complex, salt, solvate, tautomeric form or polymorphic form thereof, of a pharmaceutical composition, as defined by claim 35, for use in modulating the STimulator of INterferon Genes (STING) protein. 38. A compound, as defined in any one of claims 1 to 34, or a pharmaceutically acceptable complex, salt, solvate, tautomeric form or polymorphic form thereof, of a pharmaceutical composition, as defined by claim 35, for use in treating, ameliorating or preventing a disease selected from liver fibrosis, fatty liver disease, non-alcoholic steatohepatitis (NASH), pulmonary fibrosis, lupus, sepsis, rheumatoid arthritis (RA), type I diabetes, STING-associated vasculopathy with onset in infancy (SAVI), Aicardi- Goutieres syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus (SLE), retinal vasculopathy, neuroinflammation, systemic inflammatory response syndrome, pancreatitis, cardiovascular disease, renal fibrosis, stroke and age- related macular degeneration (AMD).

39. The compound or composition for use according to claim 38, wherein the disease is fibrosis, and the fibrosis is selected from the group consisting of liver fibrosis, pulmonary fibrosis or renal fibrosis. 40. The compound or composition for use according to claim 38, wherein the disease is fatty liver disease, and the fatty liver disease is non-alcoholic (or simple) fatty liver or non-alcoholic steatohepatitis (NASH).