SMALL MOLECULES AND A PHARMACOPHORE MODEL FOR INHIBITION OF ANTHRAX LETHAL FACTOR

Title:

SMALL MOLECULES AND A PHARMACOPHORE MODEL FOR INHIBITION OF ANTHRAX LETHAL FACTOR

Document Type and Number:

WIPO Patent Application WO2005109304

Kind Code:

A8

Abstract:

Disclosed herein is a pharmacophore model for inhibiting anthrax lethal factor protease activity which comprises a first aromatic center A, a second aromatic center B, a first polar center C, a second polar center D, a third polar center E, and a neutral linker F. Also disclosed are small molecules fitting the pharmacophore model and compositions and methods of using thereof.

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Inventors:

BAVARI SINA (US)
PANCHAL REKHA (US)

Application Number:

PCT/US2004/043273

Publication Date:

September 14, 2006

Filing Date:

December 20, 2004

Export Citation:

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Assignee:

OMMAND UNITED STATES ARMY MEDI (US)
BAVARI SINA (US)
PANCHAL REKHA (US)

International Classes:

A61K31/137; C12Q1/18; C12Q1/37; G01N33/48; G01N33/50; G06G7/48; G06G7/58; G16C20/64

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