Title:
SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS
Document Type and Number:
WIPO Patent Application WO2001083436
Kind Code:
A3
Abstract:
The present invention relates to compounds of formula (I) (where the variables RA, RB, RC and n are as defined in the claims) and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabelled metal complexes. Preferred radiolabelled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumour/nontumour ratios of the technetium complexes of the invention indicated that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods for treatment of tumours using a radiolabelled metal complex as a radiopharmaceutical agent to treat the tumor.
Inventors:
MAHMOOD ASHFAQ (US)
FRIEBE MATTHAIS (DE)
BOLZATI CHRISTINA (IT)
JONES ALUN G (US)
DAVISON ALAN (US)
FRIEBE MATTHAIS (DE)
BOLZATI CHRISTINA (IT)
JONES ALUN G (US)
DAVISON ALAN (US)
Application Number:
PCT/US2001/013550
Publication Date:
June 20, 2002
Filing Date:
April 27, 2001
Export Citation:
Assignee:
HARVARD COLLEGE (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MAHMOOD ASHFAQ (US)
FRIEBE MATTHAIS (DE)
BOLZATI CHRISTINA (IT)
JONES ALUN G (US)
DAVISON ALAN (US)
MASSACHUSETTS INST TECHNOLOGY (US)
MAHMOOD ASHFAQ (US)
FRIEBE MATTHAIS (DE)
BOLZATI CHRISTINA (IT)
JONES ALUN G (US)
DAVISON ALAN (US)
International Classes:
A61K51/00; A61K31/555; A61K51/04; A61P35/00; C07C323/41; C07C323/58; C07D295/13; C07F13/00; C07K5/06; (IPC1-7): C07C323/41; C07D295/12; C07K5/06; A61K51/04
Foreign References:
| US5919934A | 1999-07-06 | |||
| EP0200211A1 | 1986-11-05 | |||
| US4638051A | 1987-01-20 |
Other References:
P. AUZELOUX, ET AL.: "A potential melanoma tracer: synthesis, radiolabelling, and biodistribution in mice of a new nitridotechnetium bis(aminothiol) derivative pharmacomodulated by a N-(diethylaminoethyl)benzamide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 2, 27 January 2000 (2000-01-27), American Chemical Society, Washington, DC, US, pages 190 - 198, XP002193430, ISSN: 0022-2623
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