Title:
SNAKE VENOM C FRAGMENT POLYPEPTIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/190263
Kind Code:
A1
Abstract:
Provided are derivatives of a snake venom C fragment straight-chain polypeptide and a cyclic peptide related thereto, and a preparation method therefor. The derivatives comprise a parent peptide sequence as shown in formula I: R1-P1-Asp-His-P2-Gly-Thr-Arg-Ile-Glu-P3-R2 or formula II: Cyclo(Cys-Xaa1-Xaa2-Xaa3-Xaa4-Lys-Asp-His-P2-Ge-Thr-Arg-Ile-Glu-P3). The derivatives are prepared by means of a polypeptide solid phase synthesis method and can be used in the preparation of analgesic drugs.
Inventors:
MENG QINGXIONG (CN)
LIU ZICHENG (CN)
WU LIFEN (CN)
YAO ZHIYONG (CN)
LI XINYU (CN)
ZHI QIN (CN)
LIU ZICHENG (CN)
WU LIFEN (CN)
YAO ZHIYONG (CN)
LI XINYU (CN)
ZHI QIN (CN)
Application Number:
PCT/CN2016/080861
Publication Date:
November 09, 2017
Filing Date:
May 03, 2016
Export Citation:
Assignee:
SHENZHEN JYMED TECH CO LTD (CN)
International Classes:
C07K4/12; A61K38/17; A61P25/00
Foreign References:
| CN1343689A | 2002-04-10 |
Other References:
MAEDA, N.: "Isolation, properties and amino acid sequences of three neurotoxins from the venom of a sea snake, Aipysurus laevis", BIOCHEMICAL JOURNAL, vol. 153, no. 1, 1 January 1976 (1976-01-01), pages 79 - 87, XP055601778, ISSN: 0264-6021, DOI: 10.1042/bj1530079
CHENG, Y.: "Structure-function relationship of three neurotoxins from the venom of Naja kaouthia: a comparison between the NMR-derived structure of NT2 with its homologues, NT1 and NT3", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1594, no. 2, 31 December 2002 (2002-12-31), pages 353 - 363, XP004344870, DOI: 10.1016/S0167-4838(01)00326-0 LNKA
CHENG, Y.: "Structure-function relationship of three neurotoxins from the venom of Naja kaouthia: a comparison between the NMR-derived structure of NT2 with its homologues, NT1 and NT3", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1594, no. 2, 31 December 2002 (2002-12-31), pages 353 - 363, XP004344870, DOI: 10.1016/S0167-4838(01)00326-0 LNKA
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