Title:
SODIUM CHANNEL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2006/025517
Kind Code:
A1
Abstract:
A sodium channel inhibitor containing as an active ingredient a piperidine derivative or a pharmaceutically acceptable salt thereof. Also provided is the derivative or salt. The derivative or salt has a structure in which the piperidine ring is directly bonded to a benzene ring or heteroring and this benzene ring or heteroring is directly bonded to another benzene ring. The compounds not only have a high analgesic effect on neurogenic pains but are reduced in side effects.
Inventors:
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
Application Number:
PCT/JP2005/016085
Publication Date:
March 09, 2006
Filing Date:
September 02, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KIKUCHI KAZUMI (JP)
FUJIYASU JIRO (JP)
WATANABE TOSHIHIRO (JP)
NAGAKURA YUKINORI (JP)
TOMIYAMA HIROSHI (JP)
SONEGAWA MOTOHARU (JP)
TOKUZAKI KAZUO (JP)
IWAI YOSHINORI (JP)
International Classes:
C07D211/10; A61K31/4465; A61K31/4535; A61P25/04; C07D211/18; C07D211/22; C07D409/04
Domestic Patent References:
| WO2003084948A1 | 2003-10-16 |
Foreign References:
| JP2004517121A | 2004-06-10 | |||
| US3262938A | 1966-07-26 | |||
| US3256289A | 1966-06-14 |
Other References:
HARRISON E.A. ET AL: "Evidence for separation of anesthetic activity from prototypic phencyclidine action in drug discrimination by molecular modification of dioxadrol, a phencyclidine-like dissociative anesthetic", NIDA RES. MONOGR., vol. 55, 1984, pages 90 - 96, XP002994823
CREVELING C.R. ET AL: "Local anesthetic properties of opioids and phencyclidines: interaction with the voltage-dependent, batrachotoxin binding site in sodium channels", NEUROPEPTIDES, vol. 5, no. 4-6, 1985, pages 353 - 356, XP002994824
DATABASE STN [online] 15 January 2002 (2002-01-15), XP002994825, Database accession no. 383128-27-6
CREVELING C.R. ET AL: "Local anesthetic properties of opioids and phencyclidines: interaction with the voltage-dependent, batrachotoxin binding site in sodium channels", NEUROPEPTIDES, vol. 5, no. 4-6, 1985, pages 353 - 356, XP002994824
DATABASE STN [online] 15 January 2002 (2002-01-15), XP002994825, Database accession no. 383128-27-6
Attorney, Agent or Firm:
Watanabe, Kazuhira (No.8 Kikuboshi Tower Building 20-18,
Asakusabashi 3-chom, Taito-ku Tokyo 53, JP)
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