Title:
SODIUM CHANNEL REGULATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/046253
Kind Code:
A1
Abstract:
Provided in the present invention are a sodium channel regulator and the use thereof. The sodium channel regulator of the present invention has a brand-new structure and has an excellent in-vitro inhibitory effect on Nav 1.8. The compound or a pharmaceutically acceptable salt thereof according to the present invention can be used for treating sodium channel-related diseases, including pain, multiple sclerosis, Charcot-Marie-Tooth, incontinence, pathological cough or arrhythmia.
Inventors:
DUAN SHUDONG (CN)
DU SHUQI (CN)
WANG XINFENG (CN)
CHEN LEI (CN)
QIN JIHONG (CN)
DU SHUQI (CN)
WANG XINFENG (CN)
CHEN LEI (CN)
QIN JIHONG (CN)
Application Number:
PCT/CN2023/115177
Publication Date:
March 07, 2024
Filing Date:
August 28, 2023
Export Citation:
Assignee:
SHANGHAI HUILUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D405/12; A61K31/341; A61K31/343; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/401; A61K31/4025; A61K31/403; A61K31/4035; A61K31/404; A61K31/423; A61K31/425; A61K31/428; A61K31/4375; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/47; A61K31/4725; A61K31/496; A61K31/501; A61K31/502; A61K31/517; A61K31/519; A61K31/541; A61K31/549; A61P29/00; C07D207/16; C07D209/34; C07D209/52; C07D213/81; C07D307/24; C07D307/937; C07D333/38; C07D401/12; C07D403/12; C07D405/10; C07D405/14; C07D407/10; C07D409/12; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D487/04
Domestic Patent References:
| WO2022256622A1 | 2022-12-08 | |||
| WO2022256676A1 | 2022-12-08 | |||
| WO2022256702A1 | 2022-12-08 | |||
| WO2022256842A1 | 2022-12-08 | |||
| WO2022256679A1 | 2022-12-08 |
Foreign References:
| CN114945566A | 2022-08-26 | |||
| CN111065383A | 2020-04-24 | |||
| CN113272293A | 2021-08-17 | |||
| US20070185056A1 | 2007-08-09 |
Other References:
DATABASE Registry 25 December 2022 (2022-12-25), ANONYMOUS: "2-Furancarboxamide, 3-(3,4-difluoro-2-methoxyphenyl)-N-[2-(1,2- dihydroxyethyl)-4-pyridinyl]tetrahydro-4,5-dimethyl-, (2R,3S,4S,5S)- (CA INDEX NAME)", XP093142944, retrieved from STNext Database accession no. 2875496-29-8
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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