Title:
SOLID DISPERSION OF POORLY SOLUBLE DRUG
Document Type and Number:
WIPO Patent Application WO/2020/116447
Kind Code:
A1
Abstract:
As a result of providing a solid dispersion containing (2E)-3-{2,6-dichloro-4-[(4-{3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl}-1,3-thiazole-2-yl)carbamoyl]phenyl}-2-methyl-2-propenoic acid or a pharmaceutically acceptable salt thereof and a water-soluble polymer, the water solubility of the compound increases, and thus, the absorbability of the compound increases when orally administered.
Inventors:
SAKUMA SATOSHI (JP)
Application Number:
PCT/JP2019/047231
Publication Date:
June 11, 2020
Filing Date:
December 03, 2019
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
A61K31/426; A61K9/14; A61K9/20; A61K9/48; A61K47/32; A61K47/38
Domestic Patent References:
| WO2009017098A1 | 2009-02-05 |
Other References:
UEDA, HIROSHI: "Importance of solid physical property evaluation in formulation development of amorphous drug", FARUMASHIA, vol. 52, no. 5, 2016, pages 392 - 396, XP009520816, ISSN: 2189-7026, DOI: 10.14894/faruawpsj.52.5_392
TANNO, FUMIE: "Evaluation of Characteristics of Hypromellose Acetate Succinate (HPMCAS) as a Carrier for Solid Dispersion", JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 73, no. 4, 2013, Japan, pages 214 - 222, XP009520813, ISSN: 0372-7629, DOI: 10.14843/jpstj.73.214
CURATOLO, W. ET AL.: "Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu", PHARM. RES., vol. 26, no. 6, 2009, pages 1419 - 1431, XP019686188, DOI: 10.1007/s11095-009-9852-z
FRIESIN, D.T. ET AL.: "Hydroxypropyl methylcellulose acetate succinate-based spray- bried dispersions: an overview", MOL. PHARM., vol. 5, no. 6, 2008, pages 1003 - 1019, XP055056966, DOI: 10.1021/mp8000793
SUN, D.D. ET AL.: "Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers", J. CONTROL. RELEASE, vol. 211, 2015, pages 85 - 93, XP029205133, DOI: 10.1016/j.jconrel.2015.06.004
BAGHEL, S. ET AL.: "Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs", J. PHARM. SCI., vol. 105, no. 9, 2016, pages 2527 - 2544, XP055430383, DOI: 10.1016/j.xphs.2015.10.008
TANNO, FUMIE: "Evaluation of Characteristics of Hypromellose Acetate Succinate (HPMCAS) as a Carrier for Solid Dispersion", JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 73, no. 4, 2013, Japan, pages 214 - 222, XP009520813, ISSN: 0372-7629, DOI: 10.14843/jpstj.73.214
CURATOLO, W. ET AL.: "Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu", PHARM. RES., vol. 26, no. 6, 2009, pages 1419 - 1431, XP019686188, DOI: 10.1007/s11095-009-9852-z
FRIESIN, D.T. ET AL.: "Hydroxypropyl methylcellulose acetate succinate-based spray- bried dispersions: an overview", MOL. PHARM., vol. 5, no. 6, 2008, pages 1003 - 1019, XP055056966, DOI: 10.1021/mp8000793
SUN, D.D. ET AL.: "Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers", J. CONTROL. RELEASE, vol. 211, 2015, pages 85 - 93, XP029205133, DOI: 10.1016/j.jconrel.2015.06.004
BAGHEL, S. ET AL.: "Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs", J. PHARM. SCI., vol. 105, no. 9, 2016, pages 2527 - 2544, XP055430383, DOI: 10.1016/j.xphs.2015.10.008
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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