Title:
SOLID DISPERSION
Document Type and Number:
WIPO Patent Application WO/2022/138549
Kind Code:
A1
Abstract:
Provided is a nintedanib-containing solid dispersion in which the amount of impurities originating from nintedanib contained therein is low. The present invention provides a solid dispersion containing the components (a) and (b) indicated below. (a) Nintedanib, a pharmaceutically acceptable salt thereof, or a solvate of such substances; (b) at least one component selected from the group consisting of sugar alcohols, hypromellose esters, (meth)acrylic acid-based polymers, hardened oils, carnauba waxes, polyalkylene glycols, and sucrose fatty acid esters.
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Inventors:
NISHIMOTO YUYA (JP)
Application Number:
PCT/JP2021/046989
Publication Date:
June 30, 2022
Filing Date:
December 20, 2021
Export Citation:
Assignee:
TOA EIYO LTD (JP)
International Classes:
A61K31/496; A61K9/20; A61K47/26; A61K47/32; A61K47/38; A61P11/00; A61P43/00
Domestic Patent References:
| WO2017077551A2 | 2017-05-11 |
Other References:
LIU HONGFEI, DU KUNYU, LI DONGLI, DU YI, XI JUMEI, XU YING, SHEN YAN, JIANG TAO, WEBSTER THOMAS J.: "A high bioavailability and sustained-release nano-delivery system for nintedanib based on electrospray technology", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. Volume 13, pages 8379 - 8393, XP055922506, DOI: 10.2147/IJN.S181002
WARASHINA, SHOGO: "Polymers used in solid dispersions and their properties", ABSTRACT OF THE 15TH PHARMACEUTICAL ADDITIVE SEMINAR, 1 January 2016 (2016-01-01), JP, pages 1 - 2, XP009538639
MORIBE, KUNIKAZU; UEDA, KEISUKE; HIGASHI, KENJIROU: "Factors Affecting Drug Dissolution from Solid Dispersion", OLEOSCIENCE, vol. 17, no. 8, 1 January 2017 (2017-01-01), JP , pages 373 - 378, XP009537862, ISSN: 1345-8949, DOI: 10.5650/oleoscience.17.373
WARASHINA, SHOGO: "Polymers used in solid dispersions and their properties", ABSTRACT OF THE 15TH PHARMACEUTICAL ADDITIVE SEMINAR, 1 January 2016 (2016-01-01), JP, pages 1 - 2, XP009538639
MORIBE, KUNIKAZU; UEDA, KEISUKE; HIGASHI, KENJIROU: "Factors Affecting Drug Dissolution from Solid Dispersion", OLEOSCIENCE, vol. 17, no. 8, 1 January 2017 (2017-01-01), JP , pages 373 - 378, XP009537862, ISSN: 1345-8949, DOI: 10.5650/oleoscience.17.373
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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