SOLID DISPERSIONS OR SOLID DISPERSION PREPARATIONS OF TRICYCLIC COMPOUNDS

WIPO Patent Application WO/1998/001122

A1

Solid dispersions or solid dispersion preparations containing tricyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof and a process for producing the same; wherein R?1�, R?2�, R?3� and R?4� are the same or different and each represents hydrogen, lower alkyl, lower alkoxy, lower alkylthio, amino, lower alkylamino, halogenated lower alkyl, halogenated lower alkoxy, halogeno, nitro, cyano, carboxy, lower alkoxycarbonyl, hydroxymethyl, CR?9�R?10�CO�2?R?11� (wherein R?9�, R?10� and R?11� are the same or different and each represents hydrogen or lower alkyl) or CONR?12�R?13� (wherein R?12� and R?13� are the same or different and each represents hydrogen or lower alkyl); R?5� represents hydrogen or lower alkyl; R?6�, R?7� and R?8� are the same or different and each represents hydrogen, lower alkyl, hydroxy, lower alkoxy, lower alkanoyloxy, lower alkylthio, thiocyanato or halogeno; X represents CH or N; Y?1�-Y?2� represents CH�2?-O, CH�3?-S(O)�n? (wherein n is 0, 1 or 2), CH�2?CH�2?, CH=CH or CON(R?14�) (wherein R?14� represents hydrogen or lower alkyl): and Z represents oxygen or sulfur.

ISHIKAWA YASUHIRO (JP)
KIGOSHI MAKOTO (JP)
GOTO TOMOHIKO (JP)
HAYAKAWA EIJI (JP)
ITO KUNIO (JP)

PCT/JP1997/002306

January 15, 1998

July 03, 1997

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KYOWA HAKKO KOGYO KK (JP)
ISHIKAWA YASUHIRO (JP)
KIGOSHI MAKOTO (JP)
GOTO TOMOHIKO (JP)
HAYAKAWA EIJI (JP)
ITO KUNIO (JP)

A61K9/14; A61K31/165; A61K31/335; A61K31/4353; A61K31/55; (IPC1-7): A61K31/165; A61K9/00; A61K31/335; A61K31/38; A61K31/55

JPH06206858A	1994-07-26
JPH05339223A	1993-12-21
JPH05132477A	1993-05-28
JPS61249914A	1986-11-07
JPH05262642A	1993-10-12

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