Title:
SOLID FORM OF DIHYDROPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/218883
Kind Code:
A1
Abstract:
Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.
Inventors:
WANG TIANMING (CN)
YANG CHENGXI (CN)
CAI JIAQIANG (CN)
LIU WEI (CN)
ZHANG BAOLEI (CN)
TIAN QIANG (CN)
SONG SHUAI (CN)
HU HAO (CN)
HAN WEIBIAO (CN)
LI YOUQIANG (CN)
CHEN XING (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
YANG CHENGXI (CN)
CAI JIAQIANG (CN)
LIU WEI (CN)
ZHANG BAOLEI (CN)
TIAN QIANG (CN)
SONG SHUAI (CN)
HU HAO (CN)
HAN WEIBIAO (CN)
LI YOUQIANG (CN)
CHEN XING (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2019/085641
Publication Date:
November 21, 2019
Filing Date:
May 06, 2019
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D417/14; A61K31/5377; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22
Domestic Patent References:
| WO2018090862A1 | 2018-05-24 | |||
| WO2015078391A1 | 2015-06-04 | |||
| WO2015144093A1 | 2015-10-01 |
Foreign References:
| CN104945395A | 2015-09-30 | |||
| CN108329308A | 2018-07-27 | |||
| US20160206616A1 | 2016-07-21 |
Other References:
DERES ET AL.: "may prevent HBV virus replication by inhibiting viral capsid protein assembly", SCIENCE, vol. 299, 2003, pages 893 - 896
BIOCHEM. PHARMACOL., vol. 66, 2003, pages 2273 - 2279
ZLOTNICK ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 8138 - 8143
SUNSHINE LAKE PHARMA CO., LTD., ANTIMICROB. AGENTS CHEMOTHER., vol. 57, 2013, pages 5344 - 5354
"General Notices", CHINESE PHARMACOPOEIA, vol. IV
See also references of EP 3766880A4
BIOCHEM. PHARMACOL., vol. 66, 2003, pages 2273 - 2279
ZLOTNICK ET AL., PROC. NATL. ACAD. SCI., vol. 102, 2005, pages 8138 - 8143
SUNSHINE LAKE PHARMA CO., LTD., ANTIMICROB. AGENTS CHEMOTHER., vol. 57, 2013, pages 5344 - 5354
"General Notices", CHINESE PHARMACOPOEIA, vol. IV
See also references of EP 3766880A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD (CN)
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