Title:
SOLID-PHASE SYNTHESIS CARRIER, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/110559
Kind Code:
A1
Abstract:
A solid-phase synthesis carrier, a preparation method therefor and the use thereof, wherein a diene cross linking agent with a similar reactivity ratio to styrene and two vinyl groups thereof not on the same benzene ring is selected as a cross linking monomer, and is subjected to suspension polymerization to obtain a porous resin. The porous resin is then functionalized to obtain a porous resin with an amino or hydroxyl functional group. Compared with existing preparation methods, the reactivity ratio of the crosslinking agent and styrene is similar, which is beneficial to improving the uniformity of the chemical structure in the resin, forming uniformly distributed active sites and channels, and is beneficial to improving the reaction efficiency and reducing the mass transfer resistance. The preparation of oligonucleotides by using such a carrier as a solid-phase synthesis carrier can improve the yield and purity of the oligonucleotides.
More Like This:
| WO/2022/112459 | LIGHT EMITTING POLYMER MATERIAL PARTICLE |
| WO/2016/053005 | BLOCK COPOLYMER |
Inventors:
WANG CHAOYANG (CN)
ZHANG CHENG (CN)
WU DAN (CN)
ZHAO WEIJIE (CN)
LI YANJUN (CN)
LIU QIONG (CN)
KOU XIAOKANG (CN)
ZHANG CHENG (CN)
WU DAN (CN)
ZHAO WEIJIE (CN)
LI YANJUN (CN)
LIU QIONG (CN)
KOU XIAOKANG (CN)
Application Number:
PCT/CN2021/077661
Publication Date:
June 02, 2022
Filing Date:
February 24, 2021
Export Citation:
Assignee:
SUNRESIN NEW MAT CO LTD (CN)
SUNRESIN NEW MAT CO LTD GAOLING (CN)
SUNRESIN NEW MAT CO LTD GAOLING (CN)
International Classes:
C08F212/08; B01J20/26; B01J20/285; C08F257/02; C08J9/00
Domestic Patent References:
| WO2006029023A2 | 2006-03-16 |
Foreign References:
| CN102020813A | 2011-04-20 | |||
| CN101076546A | 2007-11-21 | |||
| CN1583269A | 2005-02-23 | |||
| CN1460552A | 2003-12-10 | |||
| US20070144972A1 | 2007-06-28 | |||
| CN103739860A | 2014-04-23 | |||
| CN102372812A | 2012-03-14 | |||
| CN111530432A | 2020-08-14 | |||
| US8653152B2 | 2014-02-18 |
Other References:
"Chinese Master's Thesis Hunan Normal University", 1 June 2017, HUNAN NORMAL UNIVERSITY, CN, article ZHONG GUANGMING: "Synthesis and Its Adsorption Properties for the Polystyrene Resin Based Glutamic and Cysteine", pages: 1 - 59, XP055935147
"Hunan Agricultural Machinery", vol. 44, 15 September 2014, HU NAN NONG JI BIAN JI BU , CN , ISSN: 1007-8320, article WANG CHUNGFENG: "Synthesis and Adsorption Performances of the Copolymer of1,2-Bis(P-vinylphenyl)Ethane", pages: 1 - 47, XP055935158
JIANG JIEHUI: "Synthesis and Adsorption Property of Polystyrene-Isocynauric Acid Resin Based on St-BVPE Copolymer", CHINESE MASTER'S THESES FULL-TEXT DATABASE, no. 09, 1 May 2014 (2014-05-01), pages 1 - 69, XP093029056, ISSN: 1674-0246
ZHONG SHI-HUA;WANG CHUN-FENG;SONG QING-XIA;CONG FEI;GUO JUN;QU LIANG-HUA;XU MAN-CAI: "Synthesis of Hypercrosslinked Adsorbent Resin Based on the Copolymer of Styrene-Bis( p-vinylphenyl) Ethane and its Adsorption Property for Theophylline)", JOURNAL OF NATURAL SCIENCE OF HUNAN NORMAL UNIVERSITY, vol. 38, no. 6, 25 December 2015 (2015-12-25), pages 38 - 45, XP093029060, ISSN: 1000-2537, DOI: 10.7612/j.issn.1000-2537.2015.06.007
LI W.-H., STÖVER H. D. H., HAMIELEC A. E.: "Novel polystyryl resins for size exclusion chromatography", JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY, vol. 32, no. 11, 31 August 1994 (1994-08-31), US , pages 2029 - 2038, XP093029061, ISSN: 0887-624X, DOI: 10.1002/pola.1994.080321104
HE BINGLIN ET AL., REACTIVE POLYMER, vol. 12, 1990, pages 269 - 275
SUNDELL ET AL., JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY, vol. 31, 1993, pages 2305 - 2311
See also references of EP 4190825A4
"Hunan Agricultural Machinery", vol. 44, 15 September 2014, HU NAN NONG JI BIAN JI BU , CN , ISSN: 1007-8320, article WANG CHUNGFENG: "Synthesis and Adsorption Performances of the Copolymer of1,2-Bis(P-vinylphenyl)Ethane", pages: 1 - 47, XP055935158
JIANG JIEHUI: "Synthesis and Adsorption Property of Polystyrene-Isocynauric Acid Resin Based on St-BVPE Copolymer", CHINESE MASTER'S THESES FULL-TEXT DATABASE, no. 09, 1 May 2014 (2014-05-01), pages 1 - 69, XP093029056, ISSN: 1674-0246
ZHONG SHI-HUA;WANG CHUN-FENG;SONG QING-XIA;CONG FEI;GUO JUN;QU LIANG-HUA;XU MAN-CAI: "Synthesis of Hypercrosslinked Adsorbent Resin Based on the Copolymer of Styrene-Bis( p-vinylphenyl) Ethane and its Adsorption Property for Theophylline)", JOURNAL OF NATURAL SCIENCE OF HUNAN NORMAL UNIVERSITY, vol. 38, no. 6, 25 December 2015 (2015-12-25), pages 38 - 45, XP093029060, ISSN: 1000-2537, DOI: 10.7612/j.issn.1000-2537.2015.06.007
LI W.-H., STÖVER H. D. H., HAMIELEC A. E.: "Novel polystyryl resins for size exclusion chromatography", JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY, vol. 32, no. 11, 31 August 1994 (1994-08-31), US , pages 2029 - 2038, XP093029061, ISSN: 0887-624X, DOI: 10.1002/pola.1994.080321104
HE BINGLIN ET AL., REACTIVE POLYMER, vol. 12, 1990, pages 269 - 275
SUNDELL ET AL., JOURNAL OF POLYMER SCIENCE PART A: POLYMER CHEMISTRY, vol. 31, 1993, pages 2305 - 2311
See also references of EP 4190825A4
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
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