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Title:
SOLID PHASE SYNTHESIS OF LXR LIGANDS
Document Type and Number:
WIPO Patent Application WO2001077067
Kind Code:
A3
Abstract:
The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic indicators of LXR alpha function and as pharmacologically active agents. The combinatorial libraries find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.

Inventors:
MEDINA JULIO (US)
IMAZAKI NAONORI (JP)
Application Number:
PCT/US2001/011242
Publication Date:
August 14, 2003
Filing Date:
April 05, 2001
Export Citation:
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Assignee:
TULARIK INC (US)
SUMITOMO PHARMACEUTICALS (JP)
MEDINA JULIO (US)
IMAZAKI NAONORI (JP)
International Classes:
A61P9/10; C07C231/02; C07B61/00; (IPC1-7): C07C231/02; A61K31/167; A61P9/10; C07B61/00
Domestic Patent References:
WO2001060818A12001-08-23
WO2000054759A22000-09-21
Foreign References:
US5861532A1999-01-19
US5310760A1994-05-10
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