SOLUBLE α-KLOTH PROTEINS, PROTEIN FRAGMENTS, AND USES THEREOF

Title:

SOLUBLE α-KLOTH PROTEINS, PROTEIN FRAGMENTS, AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/140250

Kind Code:

A1

Abstract:

Disclosed herein are modified soluble α-Klotho proteins and isolated fragments of wildtype soluble α-Klotho protein. Also disclosed are pharmaceutical compositions including the modified soluble α-Klotho proteins and/or isolated fragments of soluble α- Klotho protein and methods of their use in treating a subject.

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Inventors:

MOHAMMADI MOOSA (US)

Application Number:

PCT/US2019/013282

Publication Date:

July 18, 2019

Filing Date:

January 11, 2019

Export Citation:

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Assignee:

UNIV NEW YORK (US)

International Classes:

C12N9/42; A61K38/00; A61K48/00; C07K14/71; C12N9/24

Foreign References:

US20150079065A1

2015-03-19

Other References:

GOETZ ET AL.: "Exploring mechanisms of FGF signalling through the lens of structural biology", NAT REV MOL CELL BIOL., vol. 14, no. 3, March 2013 (2013-03-01), pages 166 - 180, XP009175775, doi:10.1038/nrm3528

Attorney, Agent or Firm:

O'GARA, Megan, T. et al. (US)

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