Title:
SOLUBLE PROTEIN AND UTILIZATION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/054691
Kind Code:
A1
Abstract:
A method of screening a drug by using a protein and a compound obtained by this screening method. A compound or its salt inhibiting the activity or expression of the above-described protein, a neutralizing antibody against the protein, a polynucleotide complementary to a polynucleotide encoding the protein, etc. are usable as preventives and/or remedies for neurodegenerative diseases and so on. A compound or its salt enhancing the activity or expression of the above-described protein, the protein or its partial peptide, a polynucleotide encoding the protein, etc. are usable as preventives and/or remedies for cancer and so on. Furthermore, the above-described protein is useful as a reagent for screening a compound inhibiting or enhancing the activity of the protein.
Inventors:
TADA HIDEAKI (JP)
BANDO TOMOYUKI (JP)
HAYASHI AKIO (JP)
BANDO TOMOYUKI (JP)
HAYASHI AKIO (JP)
Application Number:
PCT/JP2005/021236
Publication Date:
May 26, 2006
Filing Date:
November 18, 2005
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TADA HIDEAKI (JP)
BANDO TOMOYUKI (JP)
HAYASHI AKIO (JP)
TADA HIDEAKI (JP)
BANDO TOMOYUKI (JP)
HAYASHI AKIO (JP)
International Classes:
C12N15/00; A61K45/00; A61P9/10; A61P25/28; A61P29/00; A61P37/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/16; C12N15/09; C12P21/00; C12Q1/44
Domestic Patent References:
| WO1999018126A1 | 1999-04-15 |
Other References:
BOLLEN M ET AL: "Nucleotide pyrophosphatases/phosphodiesterases on the move.", CRIT REV BIOCHEM MOL BIOL., vol. 35, no. 6, 2000, pages 393 - 432, XP002994891
GIJSBERGS R ET AL: "Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases.", J BIOL CHEM., vol. 276, no. 2, 12 January 2001 (2001-01-12), pages 1361 - 1368, XP002978120
GODING J W ET AL: "Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family.", BIOCHIM BIOPHYS ACTA., vol. 1638, no. 1, 20 May 2003 (2003-05-20), pages 1 - 19, XP004426713
KISHOREL B K ET AL: "Cellular localization of nucleotide pyrophosphatase/phosphodiesterase(NPPs) in rat kidney.", FASEB J., vol. 18, no. 4, 23 March 2004 (2004-03-23), pages 473 - 413, XP002994892
SAKAGAMI H ET AL: "Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.", J BIOL CHEM., vol. 280, no. 24, 17 June 2005 (2005-06-17), pages 23084 - 23093, XP002994893
See also references of EP 1813671A4
GIJSBERGS R ET AL: "Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases.", J BIOL CHEM., vol. 276, no. 2, 12 January 2001 (2001-01-12), pages 1361 - 1368, XP002978120
GODING J W ET AL: "Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family.", BIOCHIM BIOPHYS ACTA., vol. 1638, no. 1, 20 May 2003 (2003-05-20), pages 1 - 19, XP004426713
KISHOREL B K ET AL: "Cellular localization of nucleotide pyrophosphatase/phosphodiesterase(NPPs) in rat kidney.", FASEB J., vol. 18, no. 4, 23 March 2004 (2004-03-23), pages 473 - 413, XP002994892
SAKAGAMI H ET AL: "Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family.", J BIOL CHEM., vol. 280, no. 24, 17 June 2005 (2005-06-17), pages 23084 - 23093, XP002994893
See also references of EP 1813671A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo 13, JP)
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