SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES

WIPO Patent Application WO2006083761

A3

A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

ROHLOFF CATHERINE M (US)
CHEN GUOHUA (US)
LUK ANDREW S (US)
AYER RUPAL A (US)
HOUSTON PAUL R (US)
DESJARDIN MICHAEL A (US)
ZAMORA PAULINE (US)
LAM STAN (US)

PCT/US2006/003192

September 28, 2006

January 27, 2006

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ALZA CORP (US)
ROHLOFF CATHERINE M (US)
CHEN GUOHUA (US)
LUK ANDREW S (US)
AYER RUPAL A (US)
HOUSTON PAUL R (US)
DESJARDIN MICHAEL A (US)
ZAMORA PAULINE (US)
LAM STAN (US)

A61K9/10; A61K38/21; A61K47/14; A61K47/32

WO2004089335A2	2004-10-21
WO2005048930A2	2005-06-02

US20030180364A1	2003-09-25
US6468961B1	2002-10-22
US20040024069A1	2004-02-05
US20030108609A1	2003-06-12

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