SOLVENT-FREE METHOD FOR PREPARING LEVETIRACETAM

Title:

SOLVENT-FREE METHOD FOR PREPARING LEVETIRACETAM

Document Type and Number:

WIPO Patent Application WO/2019/028669

Kind Code:

A1

Abstract:

The present invention relates to a method for preparing levetiracetam, characterized by performing ammonolysis with liquid ammonia using (S)-α-ethyl-2-oxo-1-pyrrolidine acetate as a raw material under a solvent-free condition to obtain levetiracetam. The provided method has advantages of low three wastes and high yield and purity and meets the requirements of industrial production.

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Inventors:

PAN HONGJIE (CN)
ZHANG WENLING (CN)
WANG PENG (CN)

Application Number:

PCT/CN2017/096408

Publication Date:

February 14, 2019

Filing Date:

August 08, 2017

Export Citation:

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Assignee:

ZHEJIANG HUAHAI PHARM CO LTD (CN)
ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D207/26; C07D207/00; C07D207/27

Domestic Patent References:

WO2006095362A1

2006-09-14

Foreign References:

EP1419144B1	2008-10-08
CN101511786A	2009-08-19

Other References:

LIU, YUEJIN ET AL.: "Synthesis of Levetiracetam and Its Derivatives", CHINESE JOURNAL OF NEW DRUGS, vol. 16, no. 11, 31 December 2007 (2007-12-31), pages 860 - 864, XP055577025

Attorney, Agent or Firm:

PATENTSINO IP FIRM (CN)

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