Title:
SOS1 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/022497
Kind Code:
A1
Abstract:
Provided are a novel compound of chemical formula I and a use thereof for preventing or treating SOS1-related diseases. A novel compound according to an aspect of the present invention inhibits interaction between SOS1 and a RAS family protein or between SOS1 and RAC1 and thus is useful for preventing or treating SOS1-mediated diseases such as cancer and RASopathy.
Inventors:
YU HA NA (KR)
SHIN YOUNG SOOK (KR)
PARK DOHYUN (KR)
YOON KYEONG JIN (KR)
LIM SANG KYUN (KR)
KIM DONGGEON (KR)
KI DONG HYUK (KR)
KIM EUN-JUNG (KR)
NAM JOONWOO (KR)
HAN WOOSEOK (KR)
YU JIHYUN (KR)
KIM JI EUN (KR)
SHIN YOUNG SOOK (KR)
PARK DOHYUN (KR)
YOON KYEONG JIN (KR)
LIM SANG KYUN (KR)
KIM DONGGEON (KR)
KI DONG HYUK (KR)
KIM EUN-JUNG (KR)
NAM JOONWOO (KR)
HAN WOOSEOK (KR)
YU JIHYUN (KR)
KIM JI EUN (KR)
Application Number:
PCT/KR2022/012254
Publication Date:
February 23, 2023
Filing Date:
August 17, 2022
Export Citation:
Assignee:
KANAPH THERAPEUTICS INC (KR)
CYRUS THERAPEUTICS INC (KR)
CYRUS THERAPEUTICS INC (KR)
International Classes:
C07D237/14; A61K31/50; A61P35/00; C07D401/04; C07D405/04; C07D409/04
Domestic Patent References:
| WO2014031928A2 | 2014-02-27 | |||
| WO2019122129A1 | 2019-06-27 | |||
| WO2021127429A1 | 2021-06-24 | |||
| WO2008011557A2 | 2008-01-24 |
Foreign References:
| KR20150013563A | 2015-02-05 |
Other References:
J. MED. CHEM., vol. 64, no. 10, 2021, pages 6569 - 6580
CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 62, 2021, pages 109 - 118
CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 62, 2021, pages 109 - 118
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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