Title:
SPECIFIC MAGNETOSOME, METHOD FOR THE PRODUCTION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO1998040049
Kind Code:
A3
Abstract:
The invention relates to specific magnetosomes consisting of a magnetic iron oxide magnetite Fe3O4 monocrystal with a diameter =45 nm and a phospholipid membrane surrounding said crystal, in addition to magnetoliposomes which can be obtained from said magnetosomes by liposomal encapsulation. The invention further relates to a method for the production and use thereof as NMR contrast agents, in purging (removal of pathogenic cells), as diagnostic agents for tumoral diseases or in lymphography, for inflammatory processes, for multiple sclerosis, Alzheimer disease, Parkinson's disease and as therapeutic agents.
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Inventors:
BAEUERLEIN EDMUND (DE)
SCHUELER DIRK (DE)
RESZKA REGINA (DE)
PAEUSER SABINE (DE)
SCHUELER DIRK (DE)
RESZKA REGINA (DE)
PAEUSER SABINE (DE)
Application Number:
PCT/DE1998/000668
Publication Date:
January 07, 1999
Filing Date:
March 06, 1998
Export Citation:
Assignee:
MAX DELBRUECK CENTRUM (DE)
MAX PLANCK GESELLSCHAFT (DE)
BAEUERLEIN EDMUND (DE)
SCHUELER DIRK (DE)
RESZKA REGINA (DE)
PAEUSER SABINE (DE)
MAX PLANCK GESELLSCHAFT (DE)
BAEUERLEIN EDMUND (DE)
SCHUELER DIRK (DE)
RESZKA REGINA (DE)
PAEUSER SABINE (DE)
International Classes:
A61K9/127; C12P3/00; A61K33/26; A61K39/395; A61K41/00; A61K47/48; A61K48/00; A61K49/00; A61K49/18; A61N2/06; A61P3/00; A61P29/00; A61P35/00; C01G49/08; C12N1/20; C12N15/88; (IPC1-7): A61K9/00
Foreign References:
US4677067A | 1987-06-30 |
Other References:
CHEMICAL ABSTRACTS, Columbus, Ohio, US;
CHEMICAL ABSTRACTS, Columbus, Ohio, US; XP002900174
CHEMICAL ABSTRACTS, Columbus, Ohio, US; XP002900174
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