Title:
SPECTROMETER PROVIDED WITH PULSED ION SOURCE AND TRANSMISSION DEVICE TO DAMP ION MOTION AND METHOD OF USE
Document Type and Number:
WIPO Patent Application WO1999038185
Kind Code:
A3
Abstract:
A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.
Inventors:
KRUTCHINSKY ANDREW N (CA)
LOBODA ALEXANDRE V (CA)
SPICER VICTOR L (CA)
ENS ERICH W (CA)
STANDING KENNETH G (CA)
LOBODA ALEXANDRE V (CA)
SPICER VICTOR L (CA)
ENS ERICH W (CA)
STANDING KENNETH G (CA)
Application Number:
PCT/CA1999/000034
Publication Date:
October 21, 1999
Filing Date:
January 25, 1999
Export Citation:
Assignee:
UNIV MANITOBA (CA)
KRUTCHINSKY ANDREW N (CA)
LOBODA ALEXANDRE V (CA)
SPICER VICTOR L (CA)
ENS ERICH W (CA)
STANDING KENNETH G (CA)
KRUTCHINSKY ANDREW N (CA)
LOBODA ALEXANDRE V (CA)
SPICER VICTOR L (CA)
ENS ERICH W (CA)
STANDING KENNETH G (CA)
International Classes:
H01J1/00; H01J49/10; H01J49/40; H01J49/42; (IPC1-7): H01J49/42; H01J49/04; H01J49/40
Domestic Patent References:
| WO1999030350A1 | 1999-06-17 |
Foreign References:
| DE19511333C1 | 1996-08-08 | |||
| US5689111A | 1997-11-18 |
Other References:
KRUTCHINSKY A N ET AL: "Collisional Damping Interface for an Electrospray Ionization Time -of-Flight Mass Spectrometer", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1998 (1998-06-01), pages 569-579, XP004122896, ISSN: 1044-0305
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