SPHERICAL PROTEIN PARTICLES AND METHODS OF MAKING AND USING THEM

Title:

SPHERICAL PROTEIN PARTICLES AND METHODS OF MAKING AND USING THEM

Document Type and Number:

WIPO Patent Application WO2003000014

Kind Code:

A3

Abstract:

This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentration of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising them, for biomedical applications, including biological delivery to humans and animals. More particularly, SPPs, spherical nanocrystalline composite particles or crystalline SPPs are used as a carrier-free delivery system which can slowly release biologically active proteins to a subject, where and when they are needed.

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Inventors:

YAKOVLEVSKY KIRILL (US)
CHAMACHKINE MIKHAIL (US)
KHALAF NAZER (US)
GOVARDHAN CHANDRIKA P (US)
JUNG CHU W (US)

Application Number:

PCT/US2002/019870

Publication Date:

October 21, 2004

Filing Date:

June 21, 2002

Export Citation:

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Assignee:

ALTUS BIOLOGICS INC (US)
YAKOVLEVSKY KIRILL (US)
CHAMACHKINE MIKHAIL (US)
KHALAF NAZER (US)
GOVARDHAN CHANDRIKA P (US)
JUNG CHU W (US)

International Classes:

A61K9/16; G01N33/53; A61K9/51; A61K9/52; A61K9/54; A61K39/395; A61K48/00; A61K49/00; A61M5/307; A61P9/10; A61P11/00; A61P29/00; A61P35/00; A61P37/06; C07K1/14; C07K16/08; C07K16/18; C07K16/24; C07K16/26; C12P21/08; G01N33/577; (IPC1-7): A61K381/06

Foreign References:

US6063910A	2000-05-16
US6143211A	2000-11-07

Other References: