Title:
SPHINGOSINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/038295
Kind Code:
A1
Abstract:
Sphingosine derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein R?1¿ and R?2¿ are each hydrogen or the like; Z is NR?7¿ (wherein R?7¿ is hydrogen or the like); Y is oxygen or NR?8¿ (wherein R?8¿ is hydrogen or the like); W is oxygen or sulfur; and k is an integer of 1 to 20. The derivatives and the salts are useful as preventive or therapeutic drugs for cerebrovascular disorders such as cerebral hemorrhage and cerebral infarction; head injuries; senile dementia; degenerative diseases of cranial nerve such as Alzheimer disease and Parkinson disease; diabetes; obesity; arteriosclerosis; inflammatory diseases; immunologic diseases; cancers; kidney diseases; and heart diseases.
Inventors:
KOBORI TAKEO (JP)
SUGIMOTO KIKUO (JP)
GODA KENICHI (JP)
TAGUCHI MINORU (JP)
SUGIMOTO KIKUO (JP)
GODA KENICHI (JP)
TAGUCHI MINORU (JP)
Application Number:
PCT/JP2000/008229
Publication Date:
May 31, 2001
Filing Date:
November 22, 2000
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
SAGAMI CHEM RES (JP)
KOBORI TAKEO (JP)
SUGIMOTO KIKUO (JP)
GODA KENICHI (JP)
TAGUCHI MINORU (JP)
SAGAMI CHEM RES (JP)
KOBORI TAKEO (JP)
SUGIMOTO KIKUO (JP)
GODA KENICHI (JP)
TAGUCHI MINORU (JP)
International Classes:
A61P3/04; A61P3/10; A61P9/10; A61P13/12; A61P25/16; A61P25/28; A61P29/00; A61P35/00; C07C271/20; C07C311/53; C07C323/43; C07D233/61; C07D233/64; C07D277/46; (IPC1-7): C07C271/08; C07C271/12; C07C271/16; C07C271/20; C07C271/22; C07C271/28; C07C275/20; C07C275/42; C07C311/53; C07C323/43; C07D213/53; C07D213/75; C07D231/56; C07D233/61; C07D233/64; C07D241/20; C07D257/06; C07D277/46; C07D285/12; C07D295/12; A61K31/17; A61K31/27; A61K31/41; A61K31/416; A61K31/4164; A61K31/426; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4965; A61K31/5375; A61P3/04; A61P3/10; A61P9/10; A61P13/12; A61P25/16; A61P25/28; A61P29/00; A61P35/00
Domestic Patent References:
| WO1995021175A1 | 1995-08-10 |
Attorney, Agent or Firm:
Kitagawa, Tomizo (Ltd. Patent Division 24-1 Takata 3-chome Toshima-ku, Tokyo, JP)
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