Title:
SPIRO COMPOUND, AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/094152
Kind Code:
A1
Abstract:
The present invention relates to a spiro compound, and a preparation method and use thereof. The spiro compound is as shown in formula I, has 3CL protease inhibitory activity, can effectively inhibit RNA virus replication of protein complex hydrolysis relying on 3CL protease, and is further used for preventing or treating related diseases.
Inventors:
JIANG XIANGRUI (CN)
ZHANG LEIKE (CN)
XU ZHIJIAN (CN)
TIAN GUANGHUI (CN)
ZHANG YAN (CN)
LI ZHIQIANG (CN)
ZHANG QIUMENG (CN)
JIANG HUALIANG (CN)
XIAO GENGFU (CN)
ZHU WEILIANG (CN)
SHEN JINGSHAN (CN)
ZHANG LEIKE (CN)
XU ZHIJIAN (CN)
TIAN GUANGHUI (CN)
ZHANG YAN (CN)
LI ZHIQIANG (CN)
ZHANG QIUMENG (CN)
JIANG HUALIANG (CN)
XIAO GENGFU (CN)
ZHU WEILIANG (CN)
SHEN JINGSHAN (CN)
Application Number:
PCT/CN2023/129513
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
WUHAN INST VIROLOGY CAS (CN)
VIGONVITA LIFE SCIENCES CO LTD (CN)
WUHAN INST VIROLOGY CAS (CN)
VIGONVITA LIFE SCIENCES CO LTD (CN)
International Classes:
C07K5/065; A61K31/407; A61K31/4155; A61K31/4725; A61K31/4985; A61K31/517; A61K38/05; A61P31/14; C07D487/10; C07D519/00; C07K1/06; C07K5/062
Foreign References:
| US11325916B1 | 2022-05-10 | |||
| US11339170B1 | 2022-05-24 | |||
| CN114524821A | 2022-05-24 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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