Title:
SPIRO DERIVATIVE HAVING GPR119 AGONIST ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2012/077655
Kind Code:
A1
Abstract:
A compound represented by formula (I) (wherein X represents =C(R2)- or =N-; R1, R2 and R4 independently represent a hydrogen atom, a halogen atom, a hydroxy group or the like; R3 represents an aryl group, a heteroaryl group or the like; Y1 represents -C(R7)(R7A)- or -O-; Y2 represents -C(R5)(R5A)-C(R6)(R6A)- or -C(R6)(R6A)-; R5, R5A, R6, R6A, R7 and R7A independently represent a hydrogen atom, a hydroxy group, a halogen atom, an alkyl group or the like; R8 represents a formula -(CR8AR8B)p-R8C or the like (wherein R8A and R8B independently represent a hydrogen atom or the like; p represents an integer of 0-3; and R8C represents an aryl group, a heteroaryl group, a cycloalkyl group or the like); m and n independently represent 0, 1 or 2; R9's independently represent a halogen atom or the like; and r represents an integer of 0-12, wherein, when r is 2 or greater, two R9's that are bound to the same carbon atom may together form an oxo), a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt.
Inventors:
OGAWA TOMOYUKI (JP)
TANAKA SATORU (JP)
OKANO AZUSA (JP)
KATO TERUKAZU (JP)
YARI HIROSHI (JP)
MASUDA KOJI (JP)
NAKAJIMA MADO (JP)
YONEHARA MITSUHIRO (JP)
WATANABE KANA (JP)
KIDA SHIRO (JP)
WADA TOSHIHIRO (JP)
TANAKA SATORU (JP)
OKANO AZUSA (JP)
KATO TERUKAZU (JP)
YARI HIROSHI (JP)
MASUDA KOJI (JP)
NAKAJIMA MADO (JP)
YONEHARA MITSUHIRO (JP)
WATANABE KANA (JP)
KIDA SHIRO (JP)
WADA TOSHIHIRO (JP)
Application Number:
PCT/JP2011/078125
Publication Date:
June 14, 2012
Filing Date:
December 06, 2011
Export Citation:
Assignee:
SHIONOGI & CO (JP)
OGAWA TOMOYUKI (JP)
TANAKA SATORU (JP)
OKANO AZUSA (JP)
KATO TERUKAZU (JP)
YARI HIROSHI (JP)
MASUDA KOJI (JP)
NAKAJIMA MADO (JP)
YONEHARA MITSUHIRO (JP)
WATANABE KANA (JP)
KIDA SHIRO (JP)
WADA TOSHIHIRO (JP)
OGAWA TOMOYUKI (JP)
TANAKA SATORU (JP)
OKANO AZUSA (JP)
KATO TERUKAZU (JP)
YARI HIROSHI (JP)
MASUDA KOJI (JP)
NAKAJIMA MADO (JP)
YONEHARA MITSUHIRO (JP)
WATANABE KANA (JP)
KIDA SHIRO (JP)
WADA TOSHIHIRO (JP)
International Classes:
C07D221/20; A61K31/438; A61K31/444; A61K31/4545; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; C07D491/107; C07D491/113; C07D491/20
Domestic Patent References:
| WO2004092179A1 | 2004-10-28 | |||
| WO2006106423A2 | 2006-10-12 | |||
| WO2009097309A1 | 2009-08-06 | |||
| WO2007088462A1 | 2007-08-09 | |||
| WO2007012661A1 | 2007-02-01 | |||
| WO2008088688A1 | 2008-07-24 | |||
| WO1999018074A1 | 1999-04-15 |
Other References:
WILSON, R. A. ET AL.: "'Synthesis and derivatisation of a novel spiro[1-benzofuran-2, 4'-piperidin]-3-one scaffold'", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 3, no. 17, 2005, pages 3228 - 3235
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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