SPIRO-LACTAM COMPOUNDS AND METHODS OF TREATING VIRAL INFECTIONS

Title:

SPIRO-LACTAM COMPOUNDS AND METHODS OF TREATING VIRAL INFECTIONS

Document Type and Number:

WIPO Patent Application WO/2021/247880

Kind Code:

A3

Abstract:

Disclosed are spiro-lactam compounds, and pharmaceutically acceptable salts thereof, that can ameliorate or treat a viral infection in a subject in need thereof. The disclosure also includes conjugates of such compounds of viral protease inhibitors with the cysteine at position or an equivalent active site cysteine on the coronavirus main protease (Mpro).

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Inventors:

KHAN M AMIN (US)

Application Number:

PCT/US2021/035724

Publication Date:

February 03, 2022

Filing Date:

June 03, 2021

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Assignee:

APTINYX INC (US)

International Classes:

A61K31/499; A61K38/55; A61K39/215; A61P31/12; A61P31/14

Domestic Patent References:

WO2018026782A1

2018-02-08

Other References:

SEPAY NAYIM ET AL: "In silico fight against novel coronavirus by finding chromone derivatives as inhibitor of coronavirus main proteases enzyme", STRUCTURAL CHEMISTRY, SPRINGER US, NEW YORK, vol. 31, no. 5, 13 May 2020 (2020-05-13), pages 1831 - 1840, XP037239362, ISSN: 1040-0400, [retrieved on 20200513], DOI: 10.1007/S11224-020-01537-5

Attorney, Agent or Firm:

BRODOWSKI, Michael (US)

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