Title:
SPIROHETEROCYCLE DERIVATIVE HAVING SEROTONIN RECEPTOR BINDING ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/048152
Kind Code:
A1
Abstract:
The present invention provides: a compound having a serotonin 5-HT2A receptor antagonist and/or inverse agonist activity or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same. A compound represented by formula (I) (in the formula, R1 represents a hydrogen atom or the like, each A1 independently represents CR2R2', each A2 independently represents CR3R3', each R2 independently represents a hydrogen atom or the like, each R2' independently represents a hydrogen atom or the like, each R3 independently represents a hydrogen atom or the like, each R3' independently represents a hydrogen atom or the like, m and n each independently represent 1 or the like, ring B represents a ring represented by formula (II) or the like (in the formula, R4 represents a group represented by formula (III) or the like (in the formula, each A3 independently represents CR13R13', each A4 independently represents CR14R14', each R13 independently represents a hydrogen atom or the like, each R13' independently represents a hydrogen atom or the like, each R14 independently represents a hydrogen atom or the like, each R14' independently represents a hydrogen atom or the like, q and r each independently represent 1 or the like, and R10 and R11 each independently represent a substituted or unsubstituted aromatic carbocyclic group or the like), and R8 represents a hydrogen atom or the like)), or a pharmaceutically acceptable salt thereof.
Inventors:
UENO TATSUHIKO (JP)
YASUI RINA (JP)
YASUI RINA (JP)
Application Number:
PCT/JP2022/035044
Publication Date:
March 30, 2023
Filing Date:
September 21, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D471/10; A61K31/438; A61K31/444; A61K31/506; A61K31/527; A61P15/10; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D498/10
Domestic Patent References:
| WO2019065791A1 | 2019-04-04 | |||
| WO2022145408A1 | 2022-07-07 |
Foreign References:
| JP2005517682A | 2005-06-16 | |||
| JP2017527630A | 2017-09-21 | |||
| JP2019535825A | 2019-12-12 | |||
| JP2008540593A | 2008-11-20 |
Attorney, Agent or Firm:
SUGITA Ken-ichi et al. (JP)
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