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Title:
SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/129679
Kind Code:
A1
Abstract:
The invention is directed to a CXCR3 antagonist comprising a compound represented by the general formula (I) (wherein all the symbols have the same meaning as defined in the description), a salt thereof, a quaternary ammonium salt thereof, an N-oxide form thereof or a solvate thereof, or a prodrug thereof. This antagonist is useful as a preventive, therapeutic and/or progression-suppressing agent for a CXCR3-mediated disease such as an immune or allergic disease [e.g., an atopic disease, an autoimmune disease (e.g., multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, glomerulonephritis, Sjogren's syndrome or the like), systemic inflammatory response syndrome (SIRS), rejection response to transplanted organ, tissue and/or cell or the like], a gastrointestinal disease [e.g., an inflammatory bowel disease or the like], or a respiratory disease [e.g., asthma, a chronic obstructive lung disease or the like].

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Inventors:
HABASHITA HIROMU (JP)
SHIBAYAMA SHIRO (JP)
Application Number:
PCT/JP2006/310814
Publication Date:
December 07, 2006
Filing Date:
May 30, 2006
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
HABASHITA HIROMU (JP)
SHIBAYAMA SHIRO (JP)
International Classes:
A61K31/499; A61K31/527; A61P1/04; A61P1/16; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P31/18; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D221/20; C07D471/10
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Attorney, Agent or Firm:
Iwatani, Ryo (Dojima 2-chome Kita-k, Osaka-shi Osaka03, JP)
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