SPIROPIPERIDINE DERIVATIVES, NOCICEPTIN RECEPTOR ANTAGONISTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT AND MEDICINAL COMPOSITIONS

Title:

SPIROPIPERIDINE DERIVATIVES, NOCICEPTIN RECEPTOR ANTAGONISTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT AND MEDICINAL COMPOSITIONS

Document Type and Number:

WIPO Patent Application WO/2002/088089

Kind Code:

A1

Abstract:

Spiropiperidine derivatives typified by compounds represented by the general formula [I]: [I] wherein the ring A, D, R¹, R^3a, R^3b, R⁴, R^5a, R^5b, R⁶, R⁷, R⁸, Ar, Y¹, Y², Y³, Y⁴,m1, n and x are each as defined in the description. These compounds have an antagonistic effect on the binding of nociceptin to a nociceptin receptor ORL1 at an extremely low concentration, which makes them useful as analgesics for cancer pain and diseases in associated with pain, antagonists to narcotic analgesic−tolerance, antagonists to narcotic analgesic−addiction or withdrawal syndrome, analgesic potentiators, antiobestics, brain function improving agents, remedies for Alzheimer’s disease, remedies for dementia, remedies for schizophrenia, remedies for degenerative neurodegenerative diseases, antidepressants, remedies for diabetes insipidus, remedies for polyuria and remedies for hypotension.

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Inventors:

SAGARA TAKESHI (JP)
ITOH SATORU (JP)
NAKASHIMA HIROSHI (JP)
GOTO YASUHIRO (JP)
SHIMIZU ATSUSHI (JP)
IWASAWA YOSHIKAZU (JP)
OKAMOTO OSAMU (JP)

Application Number:

PCT/JP2002/003878

Publication Date:

November 07, 2002

Filing Date:

April 18, 2002

Export Citation:

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Assignee:

BANYU PHARMA CO LTD (JP)
SAGARA TAKESHI (JP)
ITOH SATORU (JP)
NAKASHIMA HIROSHI (JP)
GOTO YASUHIRO (JP)
SHIMIZU ATSUSHI (JP)
IWASAWA YOSHIKAZU (JP)
OKAMOTO OSAMU (JP)

International Classes:

A61P3/04; A61P9/02; A61P13/02; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/28; A61P25/30; A61P29/00; C07D491/10; C07D491/107; (IPC1-7): C07D221/20; A61K31/438; A61K31/444; A61K31/455; A61K31/497; A61P3/04; A61P9/02; A61P13/02; A61P25/00; A61P25/04; A61P25/18; A61P25/24; A61P25/28; A61P25/30; A61P29/00; C07D403/12; C07D413/12; C07D491/107; C07D491/30

Domestic Patent References:

WO2000006545A1	2000-02-10
WO1999029696A1	1999-06-17
WO2001007050A1	2001-02-01
WO2002026714A1	2002-04-04

Foreign References:

EP1180513A1	2002-02-20
JP2001302633A	2001-10-31

Attorney, Agent or Firm:

BANYU PHARMACEUTICAL CO., LTD. (Chuo-ku, Tokyo, JP)

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