SPIROPIPERIDINE DERIVATIVES

Title:

SPIROPIPERIDINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1999/037642

Kind Code:

A1

Abstract:

[Object]: to provide compounds exhibiting antagonism to all of NK¿1?, NK¿2? and NK¿3? receptors. [Means for Solution]: compounds having general formula (I) or (II), pharmacologically acceptable salts thereof and esters or other derivatives of the same: [R?1¿ R?2¿: optionally substituted aryl, optionally substituted heteroaryl; A: CH¿2?, CO, SO¿2?; B: single bond, alkylene, alkenylene; D: O, S; E: alkylene, alkenylene; (a) : (b) or (c) (G: optionally substituted cycloalkene ring, optionally substituted cycloalkane ring; Ar: optionally substituted aryl ring, optionally substituted heteroaryl ring) R: alkyl; n: 1-3].

Inventors:

NISHI TAKAHIDE (JP)
YAMAGUCHI TAKESHI (JP)
IIO YUKIKO (JP)
TAKEMOTO TOSHIYASU (JP)
NAKAJIMA KATSUYOSHI (JP)

Application Number:

PCT/JP1999/000226

Publication Date:

July 29, 1999

Filing Date:

January 22, 1999

Export Citation:

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Assignee:

SANKYO CO (JP)
NISHI TAKAHIDE (JP)
YAMAGUCHI TAKESHI (JP)
IIO YUKIKO (JP)
TAKEMOTO TOSHIYASU (JP)
NAKAJIMA KATSUYOSHI (JP)

International Classes:

A61P11/06; C07D413/06; (IPC1-7): C07D413/06; C07D413/14; C07D417/06; C07D417/14; A61K31/435; A61K31/535; A61K31/54

Domestic Patent References:

WO1998054191A1

1998-12-03

Foreign References:

EP0776893A1	1997-06-04
JPH1143435A	1999-02-16

Other References: