Title:
SPLICING SYSTEM FOR CONTROLLING VIRUS REPLICATION IN RESPONSE TO HYPOXIC ENVIRONMENT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/082262
Kind Code:
A1
Abstract:
Provided are a splicing system for controlling virus replication in response to a hypoxic environment, and a use thereof. The system comprises, mutually separated or fused to one another, a gene encoding an hypoxia sensing unit and a gene encoding a virus replication control unit, wherein the gene encoding the hypoxia sensing unit comprises an N-terminal splicing domain element and an oxygen-sensitive protein element which are connected to one another, and the gene encoding the virus replication control unit comprises a C-terminal splicing domain element and a virus replication key factor element which are connected via a degradation subelement. The splicing system can respond to a hypoxia condition signal, thereby achieving splicing of a virus replication key factor in response to the hypoxic environment, and exhibiting characteristics of low expression of the virus replication key factor in a normal tissue environment, and enrichment in a tumor microenvironment.
Inventors:
XU JIANQING (CN)
ZHANG XIAOYAN (CN)
DING XIANGQING (CN)
LIAO QIBIN (CN)
ZHANG XIAOYAN (CN)
DING XIANGQING (CN)
LIAO QIBIN (CN)
Application Number:
PCT/CN2022/126655
Publication Date:
April 25, 2024
Filing Date:
October 21, 2022
Export Citation:
Assignee:
SHANGHAI SINOBAY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N15/62; A61K35/768; A61P35/00; C07K19/00; C12N7/01; C12R1/93
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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