Title:
STABILIZED BIODEGRADABLE NEUROTOXIN IMPLANTS
Document Type and Number:
WIPO Patent Application WO2006036202
Kind Code:
A3
Abstract:
Biodegradable neurotoxin implants and methods of malting and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time.
Inventors:
HUGHES PATRICK (US)
OLEJNIK OREST (US)
OLEJNIK OREST (US)
Application Number:
PCT/US2005/012121
Publication Date:
July 06, 2006
Filing Date:
April 08, 2005
Export Citation:
Assignee:
ALLERGAN INC (US)
HUGHES PATRICK (US)
OLEJNIK OREST (US)
HUGHES PATRICK (US)
OLEJNIK OREST (US)
International Classes:
A61L31/16; A61K39/02; A61K39/08; A61L31/06
Domestic Patent References:
| WO2001058472A2 | 2001-08-16 |
Foreign References:
| US20040033241A1 | 2004-02-19 | |||
| US20030118598A1 | 2003-06-26 | |||
| US20020098237A1 | 2002-07-25 |
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