Title:
STABILIZED PHARMACEUTICAL COMPOSITIONS COMPRISING AN HMG-COA REDUCTASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO2007071012
Kind Code:
A8
Abstract:
The present invention is a new stable drug composition particularly suitable for use as an antihypercholesterolaemic or antihyperlipidaemic agent. The present invention is specifically a drug composition comprising a pharmaceutical, a complexing agent and a surfactant, and a method for manufacturing same. When applied to unstable drugs with low solubility and poor bioavailability, like HMG-CoA reductase inhibitors and especially atorvastatin calcium amorphous form, the resulting drug composition is more stable and is characterized by an improved dissolution profile.
Inventors:
LAXMINARAYAN JOSHI (CA)
Application Number:
PCT/CA2006/000133
Publication Date:
September 13, 2007
Filing Date:
February 02, 2006
Export Citation:
Assignee:
ORBUS PHARMA INC (CA)
International Classes:
A61K31/40; A61K9/16; A61K9/20; A61K47/40; A61P3/06
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