Title:
STABILIZED THROMBIN
Document Type and Number:
WIPO Patent Application WO/2016/027263
Kind Code:
A3
Abstract:
The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
Inventors:
PILPEL YAIR (IL)
DORON SIVAN (IL)
ZHERDEV YURI (IL)
BYK-TENNENBAUM TAMARA (IL)
DORON SIVAN (IL)
ZHERDEV YURI (IL)
BYK-TENNENBAUM TAMARA (IL)
Application Number:
PCT/IL2015/000039
Publication Date:
June 02, 2016
Filing Date:
August 20, 2015
Export Citation:
Assignee:
OMRIX BIOPHARMACEUTICALS LTD (IL)
International Classes:
C12N9/74; A61K38/48; C12N15/115
Domestic Patent References:
| WO2003002592A1 | 2003-01-09 |
Other References:
K. M. BOMPIANI ET AL: "A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 10, no. 5, 1 May 2012 (2012-05-01), GB, pages 870 - 880, XP055230843, ISSN: 1538-7933, DOI: 10.1111/j.1538-7836.2012.04679.x
DOMENICA MUSUMECI ET AL: "Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer", PHARMACOLOGY & THERAPEUTICS, vol. 136, no. 2, 1 November 2012 (2012-11-01), pages 202 - 215, XP055218119, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2012.07.011
J. MÜLLER ET AL: "Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 6, no. 12, 1 December 2008 (2008-12-01), pages 2105 - 2112, XP055159657, ISSN: 1538-7933, DOI: 10.1111/j.1538-7836.2008.03162.x
DOMENICA MUSUMECI ET AL: "Polyvalent nucleic acid aptamers and modulation of their activity: a focus on the thrombin binding aptamer", PHARMACOLOGY & THERAPEUTICS, vol. 136, no. 2, 1 November 2012 (2012-11-01), pages 202 - 215, XP055218119, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2012.07.011
J. MÜLLER ET AL: "Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 6, no. 12, 1 December 2008 (2008-12-01), pages 2105 - 2112, XP055159657, ISSN: 1538-7933, DOI: 10.1111/j.1538-7836.2008.03162.x
Attorney, Agent or Firm:
CHITLARU, Edith (Bldg. 14 Weizmann Science Park,P.O. Box 619, Rehovot 01, IL)
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