Title:
STABLE FC BINDING PROTEIN, METHOD FOR PRODUCING SAID PROTEIN, AND ANTIBODY ADSORBENT IN WHICH SAID PROTEIN IS USED
Document Type and Number:
WIPO Patent Application WO/2018/198817
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing FcRn having improved stability with respect to heat and acids, a method for producing said FcRn, an antibody adsorbent in which said FcRn is used, and an antibody isolation method in which said adsorbent is used. The above problem is solved by substituting an amino acid residue at a specific position in an extracellular region of a human FcRn α chain and/or a β2 microglobulin region of a human FcRn β chain by another specific amino acid.
Inventors:
TERAO YOSUKE (JP)
YAMANAKA NAOKI (JP)
KIZU NATSUKO (JP)
ENDO SATOSHI (JP)
OE SEIGO (JP)
YAMANAKA NAOKI (JP)
KIZU NATSUKO (JP)
ENDO SATOSHI (JP)
OE SEIGO (JP)
Application Number:
PCT/JP2018/015487
Publication Date:
November 01, 2018
Filing Date:
April 13, 2018
Export Citation:
Assignee:
TOSOH CORP (JP)
International Classes:
C12N15/12; B01D15/32; B01J20/24; C07K14/735; C07K16/00; C12N1/21; C12N15/63; C12P21/02
Domestic Patent References:
| WO2010048313A2 | 2010-04-29 | |||
| WO2015199154A1 | 2015-12-30 |
Foreign References:
| JP2017118871A | 2017-07-06 | |||
| JP2018000174A | 2018-01-11 | |||
| JP2011097898A | 2011-05-19 | |||
| JP2011206046A | 2011-10-20 | |||
| JP2017086808A | 2017-05-25 |
Other References:
DATABASE UniProt [o] 30 November 2016 (2016-11-30), Database accession no. P61769
"UniProt", Database accession no. P61769
TAKAI. T., JPN. J. CLIN. IMMUNOL., vol. 28, 2005, pages 318 - 326
N. E. SIMISTER ET AL., NATURE, vol. 337, 1989, pages 184 - 187
M. RAGHAVAN ET AL., BIOCHEMISTRY, vol. 34, 1995, pages 14649 - 14657
"Structure and Function of Protein", 2005, MEDICAL SCIENCES INTERNATIONAL, LTD., pages: 9
"Molecular Cloning", 1992, COLD SPRING HARBOR LABORATORY, pages: 256
NUCLEIC ACIDS RES., vol. 30, 2002, pages e43
"UniProt", Database accession no. P61769
TAKAI. T., JPN. J. CLIN. IMMUNOL., vol. 28, 2005, pages 318 - 326
N. E. SIMISTER ET AL., NATURE, vol. 337, 1989, pages 184 - 187
M. RAGHAVAN ET AL., BIOCHEMISTRY, vol. 34, 1995, pages 14649 - 14657
"Structure and Function of Protein", 2005, MEDICAL SCIENCES INTERNATIONAL, LTD., pages: 9
"Molecular Cloning", 1992, COLD SPRING HARBOR LABORATORY, pages: 256
NUCLEIC ACIDS RES., vol. 30, 2002, pages e43
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