Title:
A STABLE PHARMACEUTICAL COMPOSITION COMPRISING AN ACID LABILE DRUG
Document Type and Number:
WIPO Patent Application WO2005092297
Kind Code:
A3
Abstract:
The present invention provides a stable pharmaceutical composition of an acid labile drug such as a pharmaceutically active substituted benzimidazole compound, comprising: a) an inner core coated with the acid labile drug; b) a first intermediate coating devoid of an alkaline stabilizing agent and the benzimidazole compound; c) a second intermediate coating comprising an alkaline stabilizing agent; and, d) an outer enteric layer. The present invention also provides a method of preparing the same.
Inventors:
DI CAPUA SIMONA (IL)
SHTERMAN NAVA (IL)
PARDO LIMOR ARI (IL)
ITACH ESTHER (IL)
SHTERMAN NAVA (IL)
PARDO LIMOR ARI (IL)
ITACH ESTHER (IL)
Application Number:
PCT/US2005/006589
Publication Date:
October 12, 2006
Filing Date:
March 02, 2005
Export Citation:
Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
DI CAPUA SIMONA (IL)
SHTERMAN NAVA (IL)
PARDO LIMOR ARI (IL)
ITACH ESTHER (IL)
TEVA PHARMA (US)
DI CAPUA SIMONA (IL)
SHTERMAN NAVA (IL)
PARDO LIMOR ARI (IL)
ITACH ESTHER (IL)
International Classes:
A61K9/50; A61K9/16; A61K9/24; A61K31/4439
Domestic Patent References:
| WO2001041734A2 | 2001-06-14 | |||
| WO1994002140A1 | 1994-02-03 | |||
| WO2000012064A1 | 2000-03-09 | |||
| WO1998019668A1 | 1998-05-14 | |||
| WO1999048498A1 | 1999-09-30 |
Foreign References:
| US6346269B1 | 2002-02-12 | |||
| GB2189698A | 1987-11-04 |
Other References:
ANONYMOUS: "Stabilized pharmaceutical composition", IP.COM, 17 September 2002 (2002-09-17), pages 1 - 2, XP002374253, Retrieved from the Internet [retrieved on 20060325]
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