STABLE PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Title:

STABLE PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/080687

Kind Code:

A1

Abstract:

The present invention relates to a composition of a ready-to-use injectable solution comprising pemetrexed or pharmaceutically acceptable salts thereof, comprising: pemetrexed; anhydrous sodium sulfite; and N-acetyl-L-cystein. With respect to use as an injectable preparation, the composition of a ready-to-use injectable solution comprising pemetrexed of the present invention is suitable for effective administration of pemetrexed since a melting process of main ingredients is not necessary before administration, and the composition can be used by being diluted immediately in a perfusate. In addition, the properties of the composition do not change even in long-term storage, and pharmaceutical stability is significantly improved by inhibiting related substances below a reference, whereby the composition can be stored in a liquid preparation state.

Inventors:

SOHN MI-WON (KR)
JANG SUN-WOO (KR)
WON DONG-HAN (KR)
KIM YONG-MIN (KR)
HWANG HYUNG-DON (KR)
MIN DONG-HUN (KR)

Application Number:

PCT/KR2015/011905

Publication Date:

May 26, 2016

Filing Date:

November 06, 2015

Export Citation:

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Assignee:

DONG A ST CO LTD (KR)

International Classes:

A61K9/08; A61K31/519; A61K47/02; A61K47/18

Domestic Patent References:

WO2014182093A1	2014-11-13
WO2012015810A2	2012-02-02

Foreign References:

KR20130122065A	2013-11-07
KR101260636B1	2013-05-13
KR20020081293A	2002-10-26

Other References: