Title:
STARCH-BASED FLUFFY PARTICLES AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/147877
Kind Code:
A1
Abstract:
Starch-based fluffy particles and a preparation method therefor and an application thereof, relating to the technical field of hemostatic materials. The preparation method for the starch-based fluffy particles comprises the following steps: (1) adding water into starch or modified starch for gelatinization to obtain starch paste; (2) adding the starch paste into an organic solvent, performing stirring, standing and centrifugation, and collecting a precipitate; and (3) performing freeze drying, crushing and sieving on the precipitate in sequence to prepare the starch-based fluffy particles. The starch-based fluffy particles are porous and fluffy, are large in particle gap, have excellent water absorption speed, water absorption rate and degradation rate, and can achieve the purpose of rapid and efficient hemostasis; and the starch-based fluffy particles are free of addition of components such as a dispersing agent, an emulsifying agent, or a cross-linking agent and have the characteristics of safety and reliability, so that the hemostatic requirement of an in-vivo environment is also satisfied.
Inventors:
TANG SHUNQING (CN)
WANG JIANJIN (CN)
GUO AIJUN (CN)
WANG JIANJIN (CN)
GUO AIJUN (CN)
Application Number:
PCT/CN2021/075416
Publication Date:
July 14, 2022
Filing Date:
February 05, 2021
Export Citation:
Assignee:
HONEST MEDICAL CHINA CO LTD (CN)
International Classes:
A61L24/00; A61L24/08
Foreign References:
| CN101423620A | 2009-05-06 | |||
| CN101559235A | 2009-10-21 | |||
| CN105688265A | 2016-06-22 | |||
| CN106377792A | 2017-02-08 | |||
| EP1178843A1 | 2002-02-13 | |||
| US20200405907A1 | 2020-12-31 | |||
| CN105617449A | 2016-06-01 | |||
| CN200710141944A | 2007-08-09 | |||
| CN200610053680A | 2006-09-29 | |||
| CN200610045441A | 2006-07-14 |
Other References:
HAN LI;ZHANG DINGKUN;ZHANG FANG;YANG YINGGUANG;YANG MING: "Preparation of Porous Starch and Research Progress in Medical Application", CHINESE TRADITIONAL PATENT MEDICINE, vol. 37, no. 6, 20 June 2015 (2015-06-20), pages 1321 - 1324, XP055949815, ISSN: 1001-1528, DOI: 10.3969/j.issn.1001-1528.2015.06.036
BIAN WENHAI;LIU CHENGCHENG;LI QIAN;WANG CHAOZHAN;BIAN LIUJIAO: "Research on the Hemostatic Preparation with Corn Microporous Starch", CURRENT BIOTECHNOLOGY, vol. 7, no. 4, 25 July 2017 (2017-07-25), pages 320 - 326+354-355, XP055949819, ISSN: 2095-2341, DOI: 10.19586/j.2095-2341.2016.0126
TIAN MENGYI;ZHENG YUZHEN;REN HUIMING;LI SAI: "Development of Starch-Based Hemostatic Materials", BEIJING BIOMEDICAL ENGINEERING, vol. 38, no. 4, 15 August 2019 (2019-08-15), pages 434 - 438, XP055949824, ISSN: 1002-3208, DOI: 10.3969/j.issn.1002-3208.2019.04.015
BIAN WENHAI;LIU CHENGCHENG;LI QIAN;WANG CHAOZHAN;BIAN LIUJIAO: "Research on the Hemostatic Preparation with Corn Microporous Starch", CURRENT BIOTECHNOLOGY, vol. 7, no. 4, 25 July 2017 (2017-07-25), pages 320 - 326+354-355, XP055949819, ISSN: 2095-2341, DOI: 10.19586/j.2095-2341.2016.0126
TIAN MENGYI;ZHENG YUZHEN;REN HUIMING;LI SAI: "Development of Starch-Based Hemostatic Materials", BEIJING BIOMEDICAL ENGINEERING, vol. 38, no. 4, 15 August 2019 (2019-08-15), pages 434 - 438, XP055949824, ISSN: 1002-3208, DOI: 10.3969/j.issn.1002-3208.2019.04.015
Attorney, Agent or Firm:
JIAQUAN IP LAW (CN)
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