Title:
STARCH-INDOLE ACID DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/066132
Kind Code:
A1
Abstract:
The present application provides a starch-indole acid derivative, a preparation method therefor, and a use thereof and relates to the technical field of modified starch. The starch-indole acid derivative refers to esterified starch generated by starch undergoing an esterification reaction together with indole acid under the action of a condensing agent and a base. The derivative has high resistance and can resist degradation in the stomach and small intestine. After reaching the colon, the derivative can be fermented by intestinal flora to release indole acid, which is beneficial to intestinal health. Compared with traditional administration methods such as gavage and intraperitoneal injection, the described means has significant advantages and can significantly increase the content of indole acid in colon and hepatic portal blood. In addition, indole acid can activate aryl hydrocarbon receptors to play an immunomodulatory role, which can be combined with the regulatory effect of starch releasing short-chain fatty acids by undergoing fermentation by intestinal flora, providing a product that synergistically exerts immune regulatory effects by means of multiple immune system signaling pathways.
Inventors:
MACKAY CHARLES REAY (CN)
SONG YINGYING (CN)
QU XINYAN (CN)
WANG QUANBO (CN)
SONG YINGYING (CN)
QU XINYAN (CN)
WANG QUANBO (CN)
Application Number:
PCT/CN2022/125134
Publication Date:
April 27, 2023
Filing Date:
October 13, 2022
Export Citation:
Assignee:
SHANDONG SHANWEI IMMUNOTECH CO LTD (CN)
International Classes:
A23L33/125; C08B31/04; A61P29/00; C08B33/02
Foreign References:
| CN113912743A | 2022-01-11 | |||
| CN109620825A | 2019-04-16 | |||
| CN109730993A | 2019-05-10 |
Other References:
彭宁福 (PEN, NINGFU): "吲哚美辛结肠靶向前药的合成以及抑制裸鼠结肠癌肝转移的研究 (Non-official translation: Synthesis of Indomethacin Colon-targeted Prodrug and Research on Inhibition of Hepatic Metastasis of Colonic Carcinoma in Nude Mouse)", 万方数据库 (WANFANG DATA), 25 September 2008 (2008-09-25), XP009545846
QIU, YUEQIN; YANG, XUEFEN; WANB, LI; JIANG, ZONGYONG: "Modulation Effect of Tryptophan Metabolites from Microbiota on Intestinal Immune and Its Mechanism", CHINESE JOURNAL OF ANIMAL NUTRITION, vol. 1, no. 31, 2 November 2018 (2018-11-02), pages 42 - 47, XP009545717
CAI, X. ; YANG, L. ; ZHANG, L.M. ; WU, Q.: "Evaluation of amylose used as a drug delivery carrier", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 345, no. 7, 7 May 2010 (2010-05-07), GB , pages 922 - 928, XP027003104, ISSN: 0008-6215
蔡祥 (CAI, XIANG): "基于多糖载体的高分子前药研究 (Non-official translation: Polymeric Prodrug Research Based on Polysaccharide Carrier)", 万方数据库 (WANFANG DATA), 21 September 2009 (2009-09-21), pages 76 - 77, XP009545843
QIU, YUEQIN; YANG, XUEFEN; WANB, LI; JIANG, ZONGYONG: "Modulation Effect of Tryptophan Metabolites from Microbiota on Intestinal Immune and Its Mechanism", CHINESE JOURNAL OF ANIMAL NUTRITION, vol. 1, no. 31, 2 November 2018 (2018-11-02), pages 42 - 47, XP009545717
CAI, X. ; YANG, L. ; ZHANG, L.M. ; WU, Q.: "Evaluation of amylose used as a drug delivery carrier", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 345, no. 7, 7 May 2010 (2010-05-07), GB , pages 922 - 928, XP027003104, ISSN: 0008-6215
蔡祥 (CAI, XIANG): "基于多糖载体的高分子前药研究 (Non-official translation: Polymeric Prodrug Research Based on Polysaccharide Carrier)", 万方数据库 (WANFANG DATA), 21 September 2009 (2009-09-21), pages 76 - 77, XP009545843
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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