STEM CELL-DERIVED EXTRACELLULAR VESICLES, AND USE THEREOF

WIPO Patent Application WO/2023/282424

A1

The present invention relates to stem cell-derived extracellular vesicles, and a use thereof. Stem cell-derived extracellular vesicles of the present invention allow one or more proteins selected from COL6A1, COL6A3, TNC, EIF4E, HSP90AB1, HSP90B1, RAC1, TGF-β1 and TGM2 to be highly expressed, so as to remarkably reduce the amounts of inflammatory cytokines such as TNF-α and IL-6, and thus are effective in the prevention, reduction, alleviation, or treatment of various inflammatory diseases. Particularly, when administered to an animal model of interstitial cystitis/bladder pain syndrome (IC/BPS), the stem cell-derived extracellular vesicles of the present invention allow the lining of the bladder, damaged during the induction of IC/BPS, to be restored, the degree of inflammation to be reduced, and bladder internal pressure to be restored, and exhibit a voiding cycle similar to that of a control group, and thus the extracellular vesicles have the excellent effect of treating interstitial cystitis/bladder pain syndrome. In addition, stem cell-derived extracellular vesicles of the present invention remarkably increase the migration of cells, and have an excellent wound healing effect, and thus can be effectively used for wound healing.

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CHO SSANG-GOO (KR)
LIM KYUNG MIN (KR)
ABDEL DAYEM AHMED (KR)
LEE SOO BIN (KR)
CHOI YUJIN (KR)
KANG GEUN-HO (KR)
KIM ARAM (KR)

PCT/KR2022/001339

January 12, 2023

January 25, 2022

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UNIV KONKUK IND COOP CORP (KR)
STEMEXONE LTD (KR)
KONKUK UNIV GLOCAL IND ACADEMIC COLLABORATION FOUND (KR)

C12N5/0775; A61K35/28; A61P13/10; A61P17/02; A61P29/00

WO2014042292A1

2014-03-20

US20180127722A1

2018-05-10

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CHUNG HYUN PATENT & LAW FIRM (KR)

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